[Animal experiment]-Preliminary exploration of using heart-specific CYP2E1 gene to modify mice to evaluate the cardiotoxicity of drugs

Two heart-specific CYP2E1 transgenic mice were used to evaluate the cardiotoxicity of sibutramine, and a more sensitive animal model was selected to evaluate the cardiotoxicity of the drug...

2020-08-24

【Animal experiment】-Tricalcium phosphate combined with bone morphogenetic protein-2/platelet-derived growth factor-BB to repair standard bone defect of SD rat skull

Observe the regenerative and repair effects of the new biological functional composite material on the standard bone defect of the SD rat skull, providing a basis for the study of bone biomaterials, bone formation and angiogenesis experimental data...

2020-08-24

【Animal Experiment】-Effect of dexmedetomidine on renal function and tight junction protein expression in septic rats

To study the effect of dexmedetomidine on renal function and tight junction protein expression in septic rats...

2020-08-24

[Animal Experiment]-Effect of Jiuxieling Granules on the expression of TLR4 and NF-κB p65 in ulcerative colitis rats with spleen and kidney yang deficiency

To investigate the effect of Jiuxu Xiening Granules on the expression of TLR4 and NF-κBp65 protein genes in the colon tissue of rats with ulcerative colitis of spleen and kidney yang deficiency...

2020-08-24

[Animal experiment]-Construction of Raf-1 gene recombinant adenovirus siRNA vector and its effect on rat cardiomyocyte hypertrophy

Construct a recombinant adenovirus vector that specifically inhibits rat Raf-1 gene, and transduce it into rat cardiomyocytes for functional identification...

2020-08-24

[Animal Experiment]-Changes of cannabinoid CB1 receptors in rats with Parkinson's disease dyskinetic syndrome due to deficiency of yin and mobilization of wind and the intervention effect of compound

To study the expression of cannabinoid CB1 receptor in the striatum of rats with Parkinson\'s disease (PD) dyskinesia (LID) and the intervention effect of compound Dihuang Fang...

2020-08-24

【Animal Experiment】-Shanghai Institute of Biological Sciences discovered a new mechanism for regulating insulin sensitivity and liver lipid metabolism in mice experiments

The international academic journal \"Diabetes\" has published online research papers by Guo Feifan\'s research group at the Shanghai Institute of Biological Sciences, Chinese Academy of Sciences. In this study, liver FOG2 played a key role ...

2020-08-24

[Animal Experiment]-Effect of Paeoniflorin on Ca2+ in Rat Dorsal Root Neurons

To establish a method to evaluate the effect of paeoniflorin on the intracellular free Ca2 + concentration of rat dorsal root ganglion neurons...

2020-08-24

【Animal experiment】-Recombinant adenovirus-mediated adiponectin gene's mechanism of effect on ApoE-/- mouse atherosclerosis

To study the inhibitory effect of adenovirus-mediated adiponectin (APN) overexpression on ApoE-/- mouse atherosclerosis (AS) and its influence on NF-κB signaling pathway...

2020-08-24

【Animal Experiment】-Biejiajian Pill's inhibitory effect on HepG2 nude mice xenograft tumor and the effect of β-catenin and Tbx3 expression in tumor tissue

To study the inhibitory effect of Biejiajian Pills on the growth of human hepatocarcinoma HepG2 xenografted tumor in nude mice and the effect of Wnt /β-catenin signaling pathway related protein expression, and to explore the molecular mechanism of Bj...

2020-08-24

[Animal experiment]-The effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw

To study the effect of thalidomide on bisphosphonate-related osteonecrosis of the jaw...

2020-08-24

[Animal experiment]-Protective effect of Apelin-13 on focal cerebral ischemia-reperfusion injury in rats

To study the protective effect of apelin-13 on focal cerebral ischemia-reperfusion injury in rats and its possible mechanism...

2020-08-24

【Animal Experiment】-The effect of morroniside on the expression of hepatocyte growth factor and von Willebrand factor in cerebral ischemia-reperfusion rat cortex

To study the effect of moloneside on the expression of hepatocyte growth factor (HGF) and von Willebrand factor (vWF) in rat cortex after 7 days of cerebral ischemia and reperfusion...

2020-08-24

[Animal experiment]-The protective effect of Nrf2 antioxidant pathway in CCl4 induced acute liver injury in rats

To study the protective effect of Nrf2 oxidative damage pathway on CCl4-induced acute liver injury in rats...

2020-08-24

[Animal experiment] The protective effect of -γ-secretase inhibitor on the white matter damage of neonatal rats induced by hyperoxia exposure

γ-secretase inhibitor (N- [N-(3,5-difluorophenylacetyl)-L-alanyl]-S-phenylglycine butyrate, DAPT) exposed to atmospheric pressure and high oxygen concentration Investigate the effect on white matter damage in newborn mice...

2020-08-22

[Animal experiment]-The mechanism of transient receptor potential channel C1 in airway remodeling in guinea pig asthma and the intervention effect of budesonide

To explore the mechanism of TRPC1 ion channel in the development of airway remodeling, and to interfere with the intervention of budesonide by blocking the expression of transient receptor potential channel C1 (TRPC1)...

2020-08-22