【Animal Modeling】-Establishment and Evaluation of Chronic Gastritis Model in Mice Infected by Helicobacter Pylori

Establish an animal model of Helicobacter pylori infection to evaluate the pathological changes of the gastric mucosa of Helicobacter pylori-related chronic gastritis...

2023-01-16

【Animal modeling】-Effect of Astragalus on endoplasmic reticulum stress response in vascular remodeling in hypertensive rats

To study the effect of Astragalus on endoplasmic reticulum stress response (ERS) in vascular remodeling in hypertensive rats, and to explore the molecular mechanism of its vascular protection...

2023-01-16

[Disease animal model]-Animal cardiomyopathy model caused by intraperitoneal injection of adriamycin

Doxorubicin 2.5 mg/kg body weight was injected intraperitoneally into Wistar rats weighing 170 to 200 g at two-week intervals three times a week, and then administered for another week...

2023-01-16

【Animal Modeling】-Expression and significance of basic leucine zipper transcription factor ATF-like protein in kidney tissue of lupus mice

To explore the expression and clinical significance of basic leucine zipper transcription factor ATF-like protein (ATF-like, BATF) in the kidney tissue of lupus mice...

2023-01-16

[Animal Modeling]-Simultaneous measurement of the brain activities of two monkeys shows that "synchronization of thoughts" or the key to primate neural mechanisms

American scientists measured the brain activity of two monkeys at the same time for the first time, and found that social interaction may lead to synchronization of monkey brain activity...

2023-01-14

【Animal modeling】-The role of stromal cell-derived factor-1 and chemokine receptor 4 in the rejection of rat corneal transplantation

To investigate the expressions of stromal cell-derived factor-1 (SDF-1) and stromal cell-derived factor-1 (CXCR4) in rat corneal tissue and their roles in immune rejection after keratoplasty...

2023-01-14

【Animal modeling】-Effect of Bushen Cuovv Decoction on ovarian morphology and sex hormones in polycystic ovary syndrome model rats

To explore the mechanism of Bushen Cuovv Decoction in the treatment of polycystic ovary syndrome by observing the effects of Bushen Cuovv Decoction on sex hormones, anti-Müllerian hormone and ovarian morphology in polycystic ovary syndrome model rats...

2023-01-14

【Animal Modeling】-Advances in animal experiments on radiation heart injury

During radiotherapy of chest and abdomen tumors, the heart located in the mediastinum is inevitably exposed to heart damage caused by radiation, collectively referred to as radiation-induced heart damage (RIHD).This disease has been considered as imp...

2023-01-14

【Animal modeling】-Construction and research of eukaryotic expression vector of full-length and mature IL-37b

To construct the eukaryotic expression vector pEGFP N1/IL-37b of full-length and mature IL-37b, and to detect the expression of both in RAW 264.7 cells...

2023-01-14

【Animal Modeling】-Comparison of Different Methods of Inducing THP-1 Cell Differentiation

To optimize different methods to stimulate the directional differentiation of THP-1 cells into M1, M2 macrophages and DC cells, and lay the foundation for the study of three in vitro cell models of M1, M2 and DC...

2023-01-14

【Animal modeling】-Effect of knockout TRPC6 on MPTP-induced neuroinflammatory injury in mice

To detect the expression of TRPC6 channel in microglia in a mouse MPTP-induced neuroinflammation model, and to explore the effect of TRPC6 channel on inflammatory expression and dopaminergic neuron damage...

2023-01-13

【Animal Modeling】-Effect of high-fat diet on insulin resistance and expression of hepatic insulin receptor substrate 1 and 2 in Tibetan miniature pigs

To investigate the effect of high-fat diet on insulin resistance (IR) and the expression of hepatic insulin receptor substrate (IRS) 1 and 2 in Tibetan miniature pigs...

2023-01-13

【Animal Modeling】-Effect of Trichinella spiralis and its worm-derived protein on cecal ligation and puncture-induced sepsis in mice

To observe the effect of Trichinella spiralis and its parasite-derived protein on cecal ligation and puncture (CLP)-induced sepsis in mice...

2023-01-13

【Animal Model】The role of atrial natriuretic peptide in the lung metastasis of melanoma in knockout mice

To investigate the effect of atrial natriuretic peptide on pulmonary metastasis of melanoma...

2023-01-13

【Animal Modeling】-Study on the Diversity of Intestinal Microflora in Common SPF Mice and Rats

To study the diversity of intestinal flora in common SPF mice and rats...

2023-01-13

【Animal Modeling】-The effect of ozone autoblood method on melatonin and oxidative stress indicators in sleep deprived rats

Observe the effects of ozone autoblood on melatonin and oxidative stress indicators in rats with insufficient sleep...

2023-01-13