【Animal Modeling】-Cyclophosphamide-induced rabbit premature ovarian failure animal model

Compare different injection methods to establish animal models of cyclophosphamide-induced primary ovarian insufficiency, find the best modeling method, and provide a more suitable experimental model for further research on early ovarian insufficienc...

2021-11-05

【Animal Modeling】-Subcutaneous injection of Mercury Nephropathy model

Replication method (1) Adult dogs, subcutaneously inject 2% mercury solution from the abdomen, the injection volume is 20 mg/kg body weight...

2021-11-05

[Animal Modeling]-Preventive administration of all-trans retinoic acid can reduce inflammation in rats with rheumatoid arthritis

To study the effect of all-trans retinoic acid (ATRA) on the structure of joint tissue, the expression level and expression of serum-related inflammatory cytokines in the arthritis model of rheumatoid arthritis (CIA) rats induced by type II collagen...

2021-11-05

[Animal Modeling]-Timing is crucial when treating mouse brain swelling

Researchers from the National Institutes of Health found that Jekyll and Hyde immune cells in the brain can eventually help repair the brain, but can cause fatal swelling early after the injury...

2021-11-05

A novel mouse model of Alzheimer's disease

Recently, researchers from the University of Oslo published a new research progress in the international academic journal brain. They knocked out two genes in the mouse brain and constructed a new mouse model of Alzheimer’s disease. Different mouse m...

2021-11-05

【Animal Modeling】-Monocular limited photocell degeneration model in rabbits

Retinitis pigmentosa is a degenerative disease of the retina that causes night blindness and eventual loss of peripheral and central visual fields...

2021-11-05

Measurement of right ventricular pressure in a mouse model of pulmonary hypertension by intercostal muscle puncture

Establish a fast and efficient method for measuring right ventricular pressure in mice without the aid of a ventilator and easy to operate, and discuss the measurement techniques...

2021-11-05

Massachusetts Institute of Technology uses CRISPR to build mouse cancer models

Genome sequencing of tumor cells has revealed thousands of cancer-related mutations. Breeding mouse strains with genetic defects is one way to reveal the effects of these mutations, but breeding such mice is a costly and time-consuming process...

2021-11-05

Exposure to environmental PCBs impairs brain function in mice

Neuroscientists at Georgetown University Medical Center say that man-made toxic chemicals that linger infinitely in the environment destroy the performance of key auxiliary cells in the mouse brain, leading to impaired function after long-term exposu...

2021-11-05

【Animal Modeling】-High-fat-induced atherosclerosis model of Wuzhishan mini-pig

Establish a high fat-induced five fat-induced atherosclerosis (AS) model, and observe the expression changes of lipoprotein-related phospholipase A2 (Lp-PLA2) in plasma and plaques...

2021-11-05

【Animal Modeling】-The role of atrial natriuretic peptide in the lung metastasis of melanoma in knockout mice

To explore the effect of atrial natriuretic peptide on pulmonary metastasis of melanoma...

2021-11-04

Establishment and analysis of hyperlipidemia cynomolgus monkey model-animal experiment

Establish a high-fat macaque model...

2021-11-04

[Disease animal model]-Diphtheria toxin-induced myocarditis in mice

For experimental mice weighing 25 to 30 g, first observe the experimental animals for 3 days, then select healthy animals and model...

2021-11-04

[Animal Modeling]-Chronic experimental epilepsy model caused by ferrous sulfate

Copy method A healthy male rabbit weighs 2-3 kg. Pentobarbital sodium is anesthetized by intravenous injection of 25-30 mg/kg body weight, fixed in a stereotactic fixation device, cut off the hair on the crown, and disinfect the skin of the surgical...

2021-11-04

【Animal Modeling】-The protective effect of bifidobacteria on liver function in rats with chronic alcoholic liver injury

Explore the protection or influence of bifidobacteria (BIFI) on liver function of rats with chronic alcoholic liver injury (chronic alcoholic hepatitis, CALI), and explore its mechanism of action?...

2021-11-04

[Disease animal model]-Miniature pig alcoholic fatty liver model

Animal models of alcoholic fatty liver are divided into two categories: acute fatty liver models and chronic fatty liver models...

2021-11-04