【Animal Modeling】-Research progress in the construction of hemophilia arthropathy model

Hemophilic arthropathy is a debilitating disease caused by spontaneous intra-articular hemorrhage and recurrent intra-articular hematoma. The main clinical manifestations are chronic pain, joint damage and poor quality of life....

2021-07-26

【Animal Modeling】-The effect of high-fat feed feeding time on type 2 diabetic nephropathy rat model

How to study the effect of different high-fat diet feeding time on blood glucose, insulin resistance index (HOMA-IR) and urinary albumin excretion rate (UAER) in type 2 diabetic nephropathy (DN) rat models?...

2021-07-22

[Animal Modeling]-Effect of Qingzao Jiufei Decoction and its decomposition agent on inflammation-related factors in the lungs of mice infected with Mycoplasma pneumoniae

TNF-α in the serum of mice infected with Mycoplasma pneumonia (MP)? INF-γ content and MPN372? P1? To explore the effect of Qingzao Jiufei Decoction (QJD) and its degradation products on lung tissues expressing AQP5, the molecular mechanism of MP infe...

2021-07-22

【Animal Modeling】-The effect of Jin Siwei on the brain cholinergic system of mice with memory impairment caused by scopolamine

To establish a memory disorder model of scopolamine and use traditional Chinese medicine compound Jin Shen to observe the effect of Jin Shen on the behavior and cholinergic system of mice with memory impairment caused by scopolamine...

2021-07-22

【Animal modeling】-Comparison of dopamine content in the lateral geniculate body of guinea pigs with flash-induced myopia and form-deprivation myopia

Observe the changes of dopamine (DA) content in the lateral geniculate body in guinea pig stroboscopic myopia and deprivation myopia models, and conduct a comparative analysis to preliminarily explore the central causes of various myopia models...

2021-07-22

【Animal Modeling】-The effect of estrogen and progesterone on the induced differential expression of αvβ3 in bovine endometrial epithelial cells in vitro

To study the induced differential expression of integrin αvβ3 gene in bovine uterine epithelial cells cultured in vitro, provide reference for exploring bovine uterine receptor marker protein?...

2021-07-22

【Animal Modeling】-Inhibition of Peripheral Neuron PAR2-PKA/PKCε Pathway on Pain Threshold of Pain Transformation Model Rats

To explore the role of peripheral neuroprotease-activated receptor 2-protein kinase A/protein kinase Cε (PAR2-PKA/PKCε) pathway in pain changes and possible solutions for simultaneous intervention in acute and chronic pain...

2021-07-22

【Animal Modeling】-Cysteinyl leukotriene receptor antagonist reduces the global cerebral ischemia-reperfusion injury of Mongolian gerbils by down-regulating autophagy

To study the protective effect and mechanism of cysteinyl leukotriene receptor antagonist (Plukast, HAMI3379) on global cerebral ischemia-reperfusion injury in gerbils...

2021-07-22

Fufang Zhenzhu Tiaozhi Capsules regulates MEKK2-Wnt coupling and antagonizes β-catenin ubiquitination to improve glucocorticoid osteoporosis in rats

To study the regulatory effects of mitogen-activated protein kinase kinase kinase 2 (MEKK2)-Wnt coupling and Pearlia Odycapsule (FTZ) intervention FTZ is a compound that antagonizes β-catenin ubiquitination and changes in bone mass. Cells that affect...

2021-07-22

【Animal Modeling】-Tempol's Effect on NF-κB Signaling Pathway in Rats with Cardiac Hypertrophy

How to study the effect of 2,2,6,6-tetramethyl-4-piperidinol (temPol) on the NF-κB signaling pathway in rat cardiac hypertrophy?...

2021-07-22

【Animal Modeling】-The neuroprotective effect of erythropoietin in a rat model of hypoxic-ischemic encephalopathy

Establish a hypoxic-ischemic encephalopathy (HIE) model in neonatal rats to show the brain protective effect of recombinant human erythropoietin (EPO) and the changes in the diversity of HIE intestinal flora in neonatal rats...

2021-07-22

【Animal Modeling】-The effects of different local intervention temperatures on the endoplasmic reticulum stress and cell apoptosis in rats with pressure ulcers

Compare the effects of different intervention temperatures on endoplasmic reticulum stress (ERS) and pressure ulcer cell apoptosis in rats, and provide experimental evidence for clinical prevention and treatment of pressure ulcers?...

2021-07-22

【Animal Modeling】-Curcumin's chemical intervention effect and mechanism analysis on N-methylnitrosourea-induced bladder cancer in rats

To analyze the chemical intervention and mechanism of curcumin on N-methylnitrosourea (MNU) induced bladder cancer rat model...

2021-07-21

[Animal Modeling]-Effects of Maca Extract on Exercise Endurance and Blood Hormone Levels in Rats

To study the effects of maca extract on exercise endurance and blood hormone levels...

2021-07-21

[Animal Modeling]-Metabonomics Study on the Changes of Metabolic Pathway During the Immunosuppressive Effect of Cyclophosphamide in Mice

Using metabonomics method to study the changes of metabolic pathways during the immunosuppressive effect of cyclophosphamide on mice...

2021-07-21

【Animal Modeling】-Analysis of Right Heart Function in Rats with Alkaline Pulmonary Hypertension

To study the relationship between changes in pulmonary artery pressure and changes in right ventricular function...

2021-07-21