[Animal modeling] Screening of differentially expressed genes and functional analysis in APP/PS1 Alzheimer's disease model mice by RNA ⁃ Seq technology

To analyze the differentially expressed genes in the prefrontal cortex of Alzheimer\'s disease (AD) model mice and reveal the pathogenesis of AD from the transcriptome level...

2022-11-03

[Animal modeling] - Expression and significance analysis of Dlx2 gene in skull tissue of young sheep skull defect model

To detect the expression of Dlx2 gene in the skull tissue of the small tailed Han sheep skull defect model, and to explore its significance for the skull defect...

2022-11-03

[Animal Modeling] - Founder α Parkinson's disease rat model with A30P mutation of synaptophysin

Founder α⁃ Parkinson\'s disease model of transgenic rats with synaptonuclein A30P mutant...

2022-11-03

[Animal modeling] - Establishment and evaluation of rat model of acute lung injury caused by smoke inhalation of simulated ship fire

To establish a rat model of acute lung injury (ALI) induced by smoke inhalation from ship fire with multiple composite materials as combustor and temperature controlled...

2022-11-03

[Animal modeling] - Comparative study on the modeling of rheumatoid arthritis in C57BL/6 mice induced by collagen and antigen

To compare the difference between the success rate of modeling collagen induced arthritis and antigen induced arthritis in C57BL/6 mice...

2022-11-03

[Animal modeling] Study on the therapeutic effect and recurrence of GnRH-a plus estrogen on rat endometriosis model

To investigate the therapeutic effect of GnRH-a plus different doses of estrogen on endometriosis and its influence on recurrence...

2022-11-03

[Animal modeling] - 3D visual modeling of kidney vessels in miniature pigs and its significance

To explore the three-dimensional visual modeling method of kidney vessels in miniature pigs and its application significance...

2022-11-03

[Animal modeling] Establishment of rat model of myocardial cell mitochondrial damage induced by bupivacaine

To observe the morphological changes of mitochondria and the production of reactive oxygen species (ROS) in cardiac myocytes induced by electric stimulation of bupivacaine, and to establish an ideal model of rat cardiac myocytes poisoned by bupivacai...

2022-11-03

[Animal modeling] - Establishment of rat fear stress model and analysis of its visual cognitive effect

To construct rat models of different levels of fear stress and explore the effect of fear stress on visual cognitive ability of LE rats...

2022-11-03

[Animal modeling] - Establishment and evaluation of visceral hypersensitivity model in rats induced by plantar electric shock

To establish rat visceral hypersensitivity animal model by foot electric shock and evaluate its effectiveness and advantages...

2022-11-03

[Animal modeling] - Identification of a mouse model of cutaneous lupus

To investigate whether the aged mice with systemic lupus erythematosus (TC) can be used as a mouse model for the study of cutaneous lupus by observing and identifying the skin symptoms...

2022-11-03

[Animal modeling] - Preliminary study on the establishment of quail gout model with high protein and high calcium diet combined with restricted drinking water

To investigate the method of establishing quail gout model by simulating clinical high protein and high calcium diet to induce Difak quail gout, so as to provide basis for the study of gout pathogenesis and screening of prevention and treatment drugs...

2022-11-03

[Animal modeling] - Comparison of bronchial asthma models induced by different doses of ovalbumin in BALB/c mice

To investigate the effects of different doses of ovalbumin on serum IgE, IL-4 and IFN in BALB/c mice with bronchial asthma γ The content, the number of eosinophils in bronchoalveolar lavage fluid and the influence of lung histopathology, initially de...

2022-11-03

[Animal modeling] - Expression and significance of thrombomodulin in deep vein thrombosis model of rats

To observe the expression and significance of thrombomodulin (TM) in the natural evolution of deep vein thrombosis (DVT) in rats...

2022-11-03

[Animal modeling] Preparation of type III Bama miniature pig model with high tyrosinemia by Hpd gene modification

Using CRISPR/Cas9 technology to knock out 4-hydroxyphenylpyruvate oxidase in Bama miniature pigs, to prepare the type III Bama miniature pig model of hypertyrosinemia...

2022-11-03

[Animal modeling] - Establishment and treatment of nude mouse model of human xenotransplantation of prostate cancer

To establish a human xenotransplantation model of prostate cancer and evaluate the anti-tumor effect of different treatment schemes...

2022-11-03