【Animal Modeling】-Effect and mechanism of different styles of music on the behavior of CUMS-depressed rats

o establish a depression model in SD rats through chronic mild and unpredictable stimulation, and to preliminarily explore the effect and mechanism of different styles of music on improving depression-like behavior in SD rats...

2022-09-24

【Animal Modeling】-Study on the safety and efficacy of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (HUC-MSCs) in the treatment of lipopolysaccharide (LPS)-induced acute lung injury in mice...

2022-09-24

【Animal Modeling】-Observation of the role of endoplasmic reticulum stress-mitochondrial autophagy pathway in pulmonary hypertension in rats

To inhibit endoplasmic reticulum stress in a rat model of pulmonary arterial hypertension induced by monocrotaline, and to observe the role of endoplasmic reticulum stress-mitochondrial pathway in pulmonary arterial hypertension in rats...

2022-09-24

【Animal Modeling】-Mechanism of Xishutongshuan Capsules attenuating cognitive impairment in rats with chronic cerebral ischemia

To study the effect of Xishuntongshuan Capsule on the rat model of chronic cerebral ischemia and its influence on the blood-brain barrier...

2022-09-24

【Animal Modeling】-Based on the rat OVX model to study the effect of estrogen deficiency on the degeneration of endplate chondrocytes

To investigate the effect of estrogen deficiency on endplate chondrocyte degeneration...

2022-09-24

【Animal modeling】-Isoproterenol-induced myocardial hypertrophy model rats based on implantable osmotic pump to improve and evaluate the conditions

Cardiac hypertrophy is a slowly developing and effective compensatory function, an adaptive response to hemodynamic or myocardial injury, and an independent risk factor for heart failure...

2022-09-24

【Animal Modeling】-Establishment of a mouse model of IgA nephropathy induced by superantigen Staphylococcus enterotoxin B

To establish a mouse model of IgA nephropathy, and to observe the biochemical and pathological characteristics of the model...

2022-09-24

【Animal modeling】-6-Hydroxydopa model rat salsolinol nitrogen methyltransferase activity detection

To establish a rat model of Parkinson\\\'s disease with 6-hydroxydopa, and to determine the activity of salsolinol nitrogen methyltransferase (SNMT) in peripheral blood lymphocytes of rats...

2022-09-24

【Animal Modeling】-Comparative study on rat models of fluorosis of different genders

To construct an animal model of male and female fluorosis rats, and to explore the gender differences of fluorosis...

2022-09-24

【Animal Modeling】-Comparison of Different Methods for Rat Model of Intrauterine Growth Retardation

Intrauterine growth retardation is manifested in the way of low birth weight of neonates? Establish IUGR model by three methods commonly used in experiments, and provide reference for the establishment of IUGR model in scientific research by comparin...

2022-09-24

【Animal Modeling】-Protective effect of Shenmai on brain tissue of mice with acute cerebral infarction and its related mechanism

To study the protective effect of Shenmai injection on the brain tissue of mice with acute cerebral infarction and to preliminarily explore its possible mechanism...

2022-09-23

【Animal Modeling】-Tumor necrosis factor-α-induced protein-8-like molecule 2 promotes apoptosis of CD4-positive T cells in heat-injured mice

To investigate the effect of tumor necrosis factor-α-induced protein-8-like molecule 2 (TIPE2) on apoptosis of spleen CD4+ T lymphocytes in a mouse model of severe scald....

2022-09-23

【Animal modeling】-FGF-2/PELA/BMP-2 microcapsule scaffold promotes the osteogenic differentiation of rat periosteum-derived stem cells

To observe the effect of fibroblast growth factor-2/polylactic acid-polyethylene glycol-polylactic acid/bone morphogenetic protein-2 (FGF-2/PELA/BMP-2) microcapsule scaffold on the formation of periosteum-derived stem cells in SD rats. Bone different...

2022-09-23

【Animal modeling】-Mechanism of recombinant adenovirus-mediated adiponectin gene on atherosclerosis in ApoE-/- mice

To study the inhibitory effect of adenovirus-mediated adiponectin (APN) overexpression on atherosclerosis (AS) in ApoE-/- mice and its effect on NF-κB signaling pathway...

2022-09-23

【Animal Modeling】-Effect of Shenzhiling Oral Liquid on Early Hippocampal Synapse and Myelin Changes in App/Ps1 Double Transgenic Mice

To observe the early neuroprotective effect of Shenzhiling oral liquid on AD mice by observing the ultrastructure of myelin sheath and synapse in the CA1 region of the hippocampus and the special staining changes of myelin sheath in 3-month-old App/P...

2022-09-23

【Animal modeling】-Effect of metformin on cognitive dysfunction and PI3K/Akt pathway in Alzheimer

To investigate the effect of metformin on phosphatidylinositol-3-kinase/protein kinase B pathway and cognitive dysfunction in Alzheimer\\\'s disease rats...

2022-09-23