【Animal Modeling】-Establishment of a nude mouse model of colon cancer liver metastasis

To construct a colon cancer liver metastasis model with high metastasis rate, simple operation and reliable results for experimental research on the prevention and treatment of colon cancer metastasis...

2022-08-29

【Animal modeling】-Hpd gene modification to prepare hypertyrosinemia type III Bama minipig model

To use CRISPR/Cas9 technology to knock out 4-hydroxyphenylpyruvate oxidase in Bama minipig to create a hypertyrosinemia type III Bama minipig model...

2022-08-29

【Animal Modeling】-Establishment and treatment of human xenograft nude mouse model of prostate cancer

To establish a human-derived xenograft model of prostate cancer and evaluate the anti-tumor effect of different treatment regimens...

2022-08-29

【Animal Modeling】-Establishment of a levofloxacin-resistant mouse model

To detect the effect of low concentration of levofloxacin on the pneumonia model of Pseudomonas aeruginosa (PA)-infected mice, and to explore the method of levofloxacin drug resistance...

2022-08-29

【Animal modeling】-Comparison of insulin resistance atherosclerosis models between white-haired black-eyed rabbits and Japanese big-eared white rabbits

To investigate the phenotypic differences and pathological mechanisms of insulin-resistant atherosclerotic models in white-haired black-eyed (WHBE) rabbits and Japanese white-eared white (JW) rabbits...

2022-08-29

【Animal Modeling】-Using the seasonal influenza virus H3N2 mouse-adapted strain to establish a mouse model

To establish a mouse model with the seasonal influenza virus H3N2 mouse-adapted strain, and to describe the molecular mechanism of the adaptation to the change of the virulence of the strain...

2022-08-29

【Animal modeling】-Tail vein injection of M1 cells to construct BALB/c nude mouse model of myeloid leukemia

To construct M1 leukemia model using BALB/c nude mice...

2022-08-29

【Animal Modeling】-Establishment and evaluation of a mouse model of endogenous infection induced by intestinal dissemination

To establish a mouse model of endogenous infection induced by intestinal dissemination, and to provide a reliable experimental model for studying the mechanism of intestinal microecology and endogenous infection...

2022-08-29

【Animal Modeling】-Establishment and preliminary analysis of the cynomolgus monkey model of hyperlipidemia

To establish a hyperlipidemia cynomolgus monkey model with similar characteristics of human diseases, and to provide an ideal animal model for the development of lipid-lowering drugs (especially biological lipid-lowering drugs)...

2022-08-29

【Animal Modeling】-Analysis of Mozart's K448 Sonata High-frequency Sound Wave on Intervention and Treatment of Depression Model in Mice

To establish a depression model in C57BL/6 mice, and to preliminarily explore the effect of high-frequency sound waves in Mozart\'s K448 sonata on improving depressive symptoms in C57BL/6 mice...

2022-08-26

【Animal Modeling】-A study on the combination of disease and syndrome of atherosclerosis (Qi stagnation and blood stasis syndrome) in rats

To construct a rat model of atherosclerosis (Qi stagnation and blood stasis syndrome) combined with disease and syndrome, and to provide an evaluation tool for the pharmacodynamics study of the corresponding traditional Chinese medicine...

2022-08-26

【Animal Modeling】-High-frequency right atrial pacing to establish a canine atrial fibrillation model and evaluation of implantable ECG monitors

In the traditional conventional high-frequency atrial pacing modeling method, innovatively use fine electrode leads, advanced catheter control system and implantable ECG monitor to track the onset of atrial fibrillation, and observe the establishment...

2022-08-26

【Animal modeling】-Using CRISPR/Cas9 gene editing technology to establish a large FcγR gene knockout mouse model

To use CRISPR/Cas9 gene editing technology to knock out the mouse FcγR2b, FcγR3, FcγR4 gene clusters with a length of about 90 kb, so as to lay the foundation for the construction of FcγR gene humanized mice...

2022-08-26

【Animal modeling】-Evaluation of motor perception behavior in non-human primate unilateral brain injury model

By evaluating the functional changes of brain regions related to brain perception and motor behavioral responses, it is an important strategy for clinical translational research on major brain diseases based on non-human primates in brain science res...

2022-08-26

【Animal modeling】-Establishment and optimization of mouse primary liver cancer model

To establish a mouse primary liver cancer model using three modeling methods, and to compare the advantages and disadvantages of each...

2022-08-26

【Animal Modeling】-Comparative study of three mouse models of early-onset ovarian insufficiency

To compare and analyze the differences of three commonly used modeling methods for early-onset ovarian insufficiency mouse models, and to explore the modeling methods that conform to the clinical characteristics of POI...

2022-08-26