【Animal Experiment】-Improving effect of treadmill exercise on locomotor function of elderly rats

Objective: To explore the changing law of motor function of aging rats and the effect of exercise on the improvement of motor function of aging rats.

  Method: SD rats aged 26 months, 8 months and 2 months were treated with moderate running exercise intervention for 2 weeks, forelimb tension, endurance, body upward movement before and after exercise, and final speed were measured. Performance indicators for comparative analysis.

  Result: ①Forelimb tension, endurance, upward movement ability and final speed of 26-month-old rats were significantly lower than those of 8-month and 2-month-old rats. The latter three index decreased with aging. The traction force of the forelimbs in the 8-month and 8-month group was higher than before exercise, while the forward force of the 8-month and 2-month group was higher than before exercise. By comparing the functional scores, the 26-month post-exercise group was significantly higher than the pre-exercise group.

   Conclusion: The four motor function indexes of rat forelimb tension, endurance, body upward movement and speed limit indicate that aging is reduced, and can be used as an aging indicator of rat motor function. Moderate-intensity treadmill exercise can significantly improve the decline of the total motor function of aging rats.