National Natural Hotspot: Super detailed! This article will help you easily understand DNA methylation [practical dry goods]

Today\\\'s short edition will introduce the natural hot spot of a country: DNA methylation. DNA methylation research has always been a multi hotspot of top journals, funding, clinical research, drug research, development and marketing...

2023-04-11

[Animal Modeling] - Su Jiacan/Chen Xiao/Jing Yingying Team Reveals Key Links in the Development of Osteoarthritis

Osteoarthritis is a total joint disease characterized by degeneration of articular cartilage, abnormal remodeling of subchondral bone, osteophyte formation, and joint inflammation. The prevalence of knee osteoarthritis in people aged 65 and above is...

2023-04-10

[Animal modeling] - Study on the safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute lung injury in mice

To investigate the safety and efficacy of human umbilical cord mesenchymal stem cells (HUC-MSCs) in the treatment of lipopolysaccharide (LPS) - induced acute lung injury in mice...

2023-02-15

[Animal modeling] - Experimental study on the colonization of two strains of CRISPR engineered Escherichia coli in mice

To evaluate the colonization ability and efficiency of two Escherichia coli engineering strains, Nissle1917 and BW25113, in the intestinal tract by using mice, so as to screen out the strains with high colonization efficiency in the intestinal tract,...

2023-02-15

[Animal modeling] - Study on the effect of dexmedetomidine combined with sufentanil on pulmonary ischemia-reperfusion injury in rats

To investigate the effect of dexmedetomidine combined with sufentanil on pulmonary ischemia-reperfusion injury (LIRI) in rats...

2023-02-09

[Animal modeling] - Resveratrol passes through HIF-1 α/ BNIP3-mediated autophagy signal pathway promotes the repair of hypoxic brain injury in mice

To explore the effect of resveratrol through HIF-1 α/ The mechanism of BNIP3-mediated autophagy signal pathway promoting the repair of hypoxic brain injury in mice...

2023-02-09

[Animal modeling] - Study on the anti-colon cancer effect of five species of Ferula in Xinjiang based on cell and animal experiments

To study the effects of five kinds of ferula from Xinjiang and their different polar parts on the proliferation inhibition and apoptosis of human colon cancer HCT 116 cells in vitro, and to study the effects of five kinds of ferula from Xinjiang on c...

2023-02-09

[Animal modeling] - Cannabinol reduces the changes of monoamine neurotransmitter induced by methamphetamine in rats

To explore the effect of cannabinol on monoamine neurotransmitters in the central nervous system in methamphetamine dependent rats, explain the therapeutic mechanism of CBD on METH dependence, and provide reference for the development of drug depende...

2023-02-09

[Animal modeling] - Shenqi Pill reduces kidney damage in diabetes ZDF rats

To investigate the intervention effect of Shenqi Pill on renal injury in diabetes ZDF rats and whether its mechanism is to reduce ERS through PERK pathway...

2023-02-08

[Animal modeling] - Effect of matrine on endothelial injury and JAK2/STAT3/SOC1 signal pathway in pregnant hypertensive rats

To investigate the effect of matrine on endothelial injury and tyrosine protein kinase 2/signal transducer and activator of transcription 3/cytokine signal transcription inhibitor 1 (JAK2/STAT3/SOSC1) signal pathway in rats with pregnancy induced hyp...

2023-02-08

[Animal modeling] - Effect of skeletal muscle specific Chrono overexpression on exercise ability and glucose tolerance in mice

The level of skeletal muscle glucose metabolism is an important factor affecting aerobic exercise ability, and the level of skeletal muscle glucose metabolism is regulated by the biological clock...

2023-02-08

[Animal modeling] - Study on the detoxification and protection mechanism of grub peptide extract on lead induced nephrotoxicity in mice

To explore the mechanism of detoxification and protection of grub peptide extract on mice by establishing a lead acetate induced nephrotoxicity model in order to provide experimental basis for the prevention and treatment of lead induced nephrosis...

2023-02-08

[Animal modeling] - protective effect of paeoniflorin on nerve injury in rats with acute cerebral infarction by activating LKB1/AMPK signal pathway

To investigate the protective effect of paeoniflorin on nerve injury in rats with acute cerebral infarction by activating hepatic kinase B1 (LKB1)/5 \'- adenosine phosphate activated protein kinase (AMPK) signal pathway...

2023-02-08

[Animal modeling] - Study on the effects of high-sugar and high-fat foods on the growth and metabolic indexes of BALB/c and C57BL/6J mice

To study the growth and metabolism of high-sugar and high-fat foods in inbred BALB/c and C57BL/6J mice, and explore the differential effects of HSHF foods on their growth and metabolism based on different strains and sexes of mice...

2023-02-08

[Animal modeling] - To explore the effect of different concentrations of Matrigel on heterotopic subcutaneous transplanted tumor of Lewis lung cancer in mice

To investigate the effect of different concentrations of Matrigel on heterotopic subcutaneous transplantation of Lewis lung cancer in mice...

2023-02-08

[Animal modeling] - Study on myocardial protection of honokiol on myocardial infarction mice

To investigate the myocardial protective effect of honokiol on acute myocardial infarction in mice and its possible regulatory mechanism...

2023-02-08