软骨细胞,动物实验 z-bo 2020-08-28 520

　　Researchers Ch at Chalmers University of Technology and Sahlgrenska Institute in Gothenburg, Sweden transplanted 3D bioprinted human chondrocytes into animals and induced their development and growth. This breakthrough may be a step towards 3D printed organs in biology.

　　The Swedish bioprinting company CELLINK has released the latest bio 3D printer BioX, which can use the latest CELLINK bioprinting technology, hardware and software to print biological materials such as heart, skin, cartilage and bones at the beginning of this year. It provides. However, although the new 3D bioprinter is CELLINK's most advanced product, its old CELLINK rewritable bioprinter has helped Swedish researchers make significant progress in bioprinting. Among many research projects aimed at promoting the development of 3D printed human organs, scientists from Sahlgrenska Institute and Chalmers Institute of Technology have transplanted human chondrocytes into animals and allowed them to grow in their hosts. Paul Gainholm, professor of biopolymer technology at Chalmers Institute of Technology, said: "This is the first time that humans have printed human cartilage cells, transplanted them into animals, and allowed them to grow."

　　The results of the Swedish researchers were published in the journal "Global Open Plastics and Reconstructive Surgery". This article describes how to use a CELLINK printer to mix nanofiber hydrogels with human chondrocytes and then implant them in mice. This new nanofiber-based biomaterial was developed by Gatenholm and his Wallenberg Wood Science Center research team. The team member is Lars Kolby, a senior lecturer at the Sahlgrenska College of Gothenburg University and an orthopedic specialist at Sahlgrenska University Hospital. Researchers were unable to determine how the mouse responded to human cartilage, but saw three very important results. Mouse blood vessels are formed in and around the material. The third is to effectively stimulate the proliferation of human stem cells and the formation of new cartilage. All three results may be very important for the field of biological 3D printing.

　　"It looks like cartilage after 60 days," Colby said. "It's white, human cartilage cells are still alive and produce what they do. You can also stimulate cartilage cells by adding stem cells to further promote cell division."

　　The researchers said: "The cooperation between the two institutions and the sharing of their respective knowledge bases are the key to the success of this project. It is usually like this: Our clinicians have solved this problem. We will use the researchers' solutions to help us "If we can get together, we will have the opportunity to actually solve some of the obstacles we face. You can make a profit."

　　It is forbidden to immediately implant 3D printed organs into the human body, but this is another important basis. Researchers based on Gatberg are critical to this, and their research will play an important role.

　　Gatenholm: "With all our efforts, this research has taken a big step towards the expected goal. We hope to be able to bioprint the cells of the patient's body. Work: a small improvement, our result is not a revolution, but The gratifying part of progress!"