大鼠模型 z-bo 2020-08-31 449

　　Kidney disease is a major unresolved health problem in the world, and the irreversibility of the progression of kidney disease has always plagued patients, doctors and researchers. Researchers at Wenzhou Medical University have used allogeneic kidney acellular biological scaffolds to successfully induce kidney regeneration in a rat model of partial nephrectomy. according to

　　According to statistics, there are 120 million kidney disease patients in China. It was once generally believed in the field of international research that vertebrates other than zebrafish could not achieve kidney regeneration in the body. In the rat model of partial nephrectomy, only weak renal tubular repair and regeneration can be detected at the stump, without glomerular regeneration and permanent loss of function. All researchers in the field of renal regeneration regard the achievement of glomerular regeneration and even functional recovery as the ultimate goal of their research.

　　The scientific research team of Wenzhou Medical University successfully prepared the kidney decellularized biological scaffold in the early stage, completely removed the rat kidney cells, and only retained the three-dimensional extracellular matrix structure of the kidney. Then, the partial nephrectomy was implanted in the rat kidney. The decellularized biological scaffold can regenerate the residual kidney in rats. The radionuclide was found by visual observation and B-ultrasound examination of the kidney after the operation, and the glomerular filtration rate gradually increased after the operation. Progenitor cells detected. And it shows a normal distribution. Associate Professor Mei Jin, director of the Institute of Biological Scaffold Transplantation and Immunology of Wenzhou Medical University, said that the research results were funded by the Zhejiang Natural Science Foundation of China and the acellular biological scaffold research group of Wenzhou Medical University. Relevant research fields have been obtained. Significant progress will open up important ways for the clinical treatment and scientific research of patients with kidney disease in the future.