动物实验,白血病干细胞 z-bo 2020-08-31 436

　　According to reports, the treatment of leukemia mainly relies on chemotherapy, but chemotherapy is difficult to remove the leukemia stem cells in the bone marrow, and the leukemia is likely to recur. So, answer the question of what happens in the bone marrow after chemotherapy starts? How leukemia stem cells escape chemotherapy and other scientific issues is critical to the study of treatment strategies. The researchers first injected human acute lymphoblastic leukemia cells into mice to establish a mouse leukemia model, and then performed chemotherapy and used advanced imaging technology for observation and research. Leukemia cells were found to infiltrate the bone marrow and proliferate. Chemotherapy is performed after the normal bone marrow microenvironment is basically destroyed. Leukemia stem cells secrete some cytokines, these cytokines will recruit and transform bone marrow mesenchymal stem cells, thereby establishing and evading temporary "sanctuary" chemotherapy killing.

　　Just like an earthquake destroyed a house, survivors set up temporary tents to survive the disaster. Researchers discovered and identified this "temporary tent" in the bone marrow and called it this new "shelter" in the NSM microenvironment. Researchers have found that disrupting the formation or protective function of the NSM microenvironment can significantly increase the effectiveness of chemotherapy and eliminate residual leukemia stem cells in the bone marrow. At the same time, microenvironmental markers were detected in the samples of leukemia patients who were not partially or partially improved by chemotherapy, but not in the samples of leukemia patients in complete remission. Experts say that the importance of research lies in the detection of markers to determine the prognosis of patients and interfere with the formation or function of patients, thereby improving the effectiveness of chemotherapy and treating leukemia.