动物实验,基因NPTX2 z-bo 2020-09-01 392

　　A study published in Cancer Research by researchers at the Mayo Clinic in Florida showed that genes that control brain growth and development are also actively involved in promoting the development of renal clear cell carcinoma, which is the most common type of renal cancer. Common form. I have confirmed. Studies have shown that the NPTX2 gene plays an important role in this type of cancer. In this study, NPTX2 is not only active in kidney cancer, but also the gene is overexpressed for the first time in human cancer. Researchers are currently looking for whether NPTX2 might play a role in other cancers. We found that genes known to play a role in a healthy brain are also related to the deadliest cancer of the urinary system. The reason why PTX2 is expressed in kidney cancer is not clear, but it is known to be expressed in kidney cancer.

　　Since the NPTX2 gene is not expressed in normal kidney tissues, drugs targeting this protein can provide targeted therapy. Lead author Christina vonoemeling (Christina vonoemeling) and colleagues analyzed the genomes of nearly 100 kidney cancer patients' samples, and which genes were overexpressed or underexpressed compared with genes in normal kidney tissue samples from matched patients. I have decided. Von Romeling (Vonoemeling) and the research team mutated and silenced the first 200 genes one by one to understand how these genes affect tumor growth. They found that 31 genes are important for the growth or survival of cancer cells, and determined that NPTX2 is an important gene for cancer survival. The co-author of the paper, Dr. Derekadisky, used nine published genome data sets to search for the NPTX2 gene in kidney cancer and found that the gene is closely related to kidney cancer. Kidney researchers also found that the receptor GluR4 (NPTX2 protein acting receptor) was also found in kidney cancer samples. They discovered how NPTX2 and GluR4 promote the growth and metastasis of cancer. In kidney cancer, the over-expressed NPTX2 protein is secreted by the cell and adheres to the kidney cancer cell membrane GluR4. PTX2 aggregates multiple GluR4 proteins to form a channel into the cell. This leads to calcium influx. Elevated calcium triggers a variety of signaling pathways, promotes cancer cell growth, and promotes tumor invasion and metastasis.

　　may block the GluR4 channel and cause cancer cell death. Researchers found that NPTX2 is expressed in all stages of kidney cancer, especially in metastases. This indicates that it plays an important role in the occurrence and development of tumors. Its expression can be used as a biomarker to test which patients will benefit from NPTX2 inhibitors.