动物实验,MDV感染,肿瘤 z-bo 2020-09-01 402

　　Marek's disease in chickens is a common infection in poultry, with Marek virus (MDV) being the main cause. A new study found that microRNA (miRNA) has a regulatory effect on MDV tumorigenesis. In order to better understand the molecular mechanism of MDV tumorigenesis, the scientific research team of the Harbin Veterinary Research Institute of the Chinese Academy of Agricultural Sciences studied the host and viral miRNA expression profiles in MDV-susceptible populations.

　　Researchers used miRNA chip technology (a miRNA chip analysis project conducted by Lianchuan Biological) to analyze the miRNA expression profile of the host and virus infected by MDV. Obvious differential expression was observed for 79 miRNAs, and the results were verified by qRT-PCR. Experimental data shows that differentially expressed miRNAs may play a major role in the tumorigenic process induced by MDV. At the same time, the researchers also found that certain host miRNAs expressed increased expression in splenic tumors and non-tumor spleen tissues of chickens infected with GA.

　　This study provides new insights into the regulation of miRNAs in MDV tumorigenesis. Several differentially expressed miRNAs can be used as markers of MDV infection and tumorigenesis.