动物实验,干细胞 z-bo 2020-09-01 425

　　A few days ago, a research team from Sun Yat-sen University's Zhongshan Eye Center and a research team from the University of California, San Diego showed for the first time that WNT7A and PAX6, the key factors regulating corneal stem cell differentiation, play an important role in corneal lineage differentiation. It is proved that it induces skin stem cells, differentiates into limbal stem cells and restores corneal function normally.

　　The representative of the

　　project said that marginal stem cell transplantation has been limited by insufficient donor sources and rejection of allogeneic transplantation. The significance of this research published in the journal Nature is that it can quickly and cheaply distinguish skin epithelial stem cells or other cell types, and expand enough limbal stem cells to repair and regenerate the corneal surface. , The treatment of limbal stem cell deficiency provides potential resources. This provides a broad application prospect for the treatment of major diseases caused by limbal stem cell dysfunction and the repair of epithelial damage after myopia.

　　The above results are the products of the National Institute of Ophthalmology, Sun Yat-sen University, actively exerting the operating mechanism of "open, mobile, collaborative, and competitive", and the platform function of the national leading laboratory is carrying out joint research and joint research. The key personnel responsible for the results include Professor Zhang Yan from the Human Genome Medicine Institute of the University of California, San Diego, director of the Zhongshan Eye Center, and Liu Kanzhi, director of the Eye Hospital.