动物实验,Omega 3脂肪酸 z-bo 2020-09-01 428

　　A new study by researchers from Duke University School of Medicine confirms that the joints of mice fed omega-3 fatty acids are healthier than those fed with high saturated fat and omega-6 fatty acids.

　　The results of this study were published in the journal "Analls ofheumatic Diseases", showing that in addition to obesity, unhealthy dietary fat may also exacerbate osteoarthritis.

　　Farshid Guilak: Our results show that dietary factors play a more important role in the link between obesity and arthritis. Obesity is one of the main risk factors for osteoarthritis, but the link mechanism between obesity and osteoarthritis is not fully understood. It is currently believed that weight gain causes joint wear and tear, but this does not explain why weightless joints such as hands also suffer from arthritis.

　　Gillac and his colleagues have begun research to study the impact of other factors on arthritis. Early studies on obese mice showed that lack of leptin can predict whether mice have arthritis. This leads me to think that this may not be weight gain, but what I eat will affect arthritis. In this study, the researchers studied mice with knee osteoarthritis caused by joint damage. Three groups of mice were fed one of three high-fat diets: a high-fat diet rich in saturated fatty acids, a high-fat diet rich in omega-6 polyunsaturated fatty acids, and a high-fat diet rich in omega-6. Fat diet 3. A high-fat diet of polyunsaturated fatty acids. Saturated fats from animals are generally known to increase cholesterol levels. Omega-6 polyunsaturated fatty acids are commonly found in corn oil, soybean oil, nuts and seeds, and are considered a healthier source of fats. Omega-3 polyunsaturated fatty acids commonly found in fish and fish oil supplements are promoted as "healthy fats" with heart health and anti-inflammatory properties. Unfortunately, most Americans eat far more saturated fats and omega-6 polyunsaturated fatty acids instead of omega-3 polyunsaturated fatty acids. The researchers found that arthritis is largely related to the diet of mice, not weight. Arthritis in mice that consumed large amounts of saturated fat or omega-6 polyunsaturated fatty acids significantly worsened. Omega-3 polyunsaturated fatty acids are irreversibly damaged, but seem to slow the development of arthritis in mice. In fact, omega-3 polyunsaturated fatty acids can eliminate the adverse effects of obese mice with multiple joints. The researchers also studied the effects of omega-3 polyunsaturated fatty acids on wound healing in mice. We pierced the ears of mice receiving omega-3 polyunsaturated fatty acids and found that the cure rate far exceeded that of mice with inedible omega-3 and unsaturated fatty acids. We found that dietary fat can regulate ear wound healing in mice, joint damage in obese mice, and the severity of osteoarthritis. Researchers are working hard to convey the research results to humans. The next step is to conduct clinical studies to study the effects of omega-3 polyunsaturated fatty acids on damage.