动物实验,肠道菌群 z-bo 2020-09-01 433

　　Recently, in research papers published in the international journal PLoSONE, researchers at Brigham and Women's Hospital often feel uncomfortable due to infections and use special computer models to make infections more natural. Clarified the impact on the flora. Molecular mechanisms and related research can help clinicians develop new therapies to treat gastrointestinal infections and inflammations.

　　Researcher Lingley said that the number of bacteria in the intestine is more than 10 times the number of somatic cells, and these complex flora ecosystems perform well in our bodies when facing infectious diseases. Greatly affect your health. In this article, researchers have developed a new type of computer algorithm that can analyze the various stages of infection caused by Citrobacter, which can cause disease in mice and manifestations of human food poisoning. Researchers have introduced Citrobacter into the intestines of mice.

　　Two months later, different levels of Citrobacter may be found in various parts of the mouse intestine. This new computer algorithm can help researchers of infectious diseases in the gut flora associated with inflammation identify changes in bacterial dynamics. When the mouse was infected, the researchers found that the normal flora in various places in the mouse's intestine was damaged a lot. For example, they found that after mice were infected with bacteria, bacterial markers appeared in the mouse colon tissue. The pre-symptomatic levels continue to decline, but the levels of other markers (including the Clostridium and Lactobacillus families) tend to increase; more interestingly, some of these markers are enteric pathogens. Occurs in the location of the host cell that did not occur, and does not directly damage the host cell.

　　From a clinical point of view, we have identified these new microbial markers, enabling clinicians to detect early inflammation or persistent drug resistance in patients with gastrointestinal diseases (such as inflammatory bowel disease). Say it can help. The many microbial markers that researchers have identified over time can help scientists develop targeted new therapies to treat infectious and inflammatory diseases.