动物实验,帕金森病 z-bo 2020-09-01 429

　　In the methamphetamine-induced Parkinson's disease model, the overexpression of α-synuclein is the main cause of death of dopaminergic neurons.

　　Dr. Wang Huijun of Southern Medical University in China found that stereotactic injection of α-syn-shRNA lentivirus can inhibit the expression of α-synmRNA and protein in the right striatum, thereby inhibiting depression in Parkinson's disease model rats. It was found that the activities of dopamine and tyrosine hydroxylase and superoxide dismutase in the striatum increased significantly, but the striatum produced reactive oxygen species, nitric oxide synthase activity and nitric oxide content. The number of apoptotic cells with reduced malondialdehyde content was significantly reduced.