动物实验,抗氧化物 z-bo 2020-09-01 426

　　Recent studies have shown that antioxidants targeting specific cytoskeleton mitochondria can mask certain side effects of arterial aging and reduce the risk of heart disease. When the team fed water containing a MitoQ four weeks later to aging mice (equivalent to 70 to 80-year-old humans), the arterial function was normal, equivalent to 25 to 35-year-old humans.

　　"The main key sign of aging is the loss of endothelial cell function," said Rachel Giociayan, a PhD in the Department of Interdisciplinary Physiology at the University of Colorado Boulder, who is the lead author of this article. I will. Achel added: "MitoQ can completely reconstruct the endothelial cell function of old mice. They look like young mice." A recent study by the University of Colorado showed that antioxidants targeting special cytoskeleton mitochondria can mask certain aspects of arterial aging. Side effects, and reduce the risk of heart disease. When the research team provided water containing a type of MitoQ to aging mice (equivalent to people aged 70 to 80), the arteries equivalent to 25 to 35 years old became functional after four weeks.

　　Researchers believe that MitoQ can affect the endothelial layer. It is a thin layer of attached cells attached to blood vessels. The important function of the endothelium is to help penetrate the artery as needed. With age, the endothelial layer gradually loses its ability to initiate expansion, which leads to an increased risk of cardiovascular disease.

　　"A key hallmark of primary aging is the loss of endothelial cell function," said Rachel Giociayan, a doctoral student in the Department of Interdisciplinary Physiology at the University of Colorado at Boulder, who is the first author of this article. I'm. MitoQ can completely reconstruct the endothelial cell function of old mice, making them look like young mice. "This research was published in the "Journal of Psychology" and was funded by the National Agency for Aging, which is one of 27 national medical institutions and centers and one of the leaders in scientifically revealing natural aging. Provided The production of nitrogen can cause vasodilation. As the body ages, more nitrous oxide will be destroyed by various reactive oxygen systems (such as superoxide). These different forms of oxygen are found in human cells Many components, such as organelles (such as mitochondria). In addition, superoxide directly reacts with the enzyme that produces NO. First, it can reduce the production of NO, which means less blood vessel penetration.

　　Even in a young and healthy body, mitochondria produce superoxide. A low level of superoxide is needed, which is done under the control of the body's own antioxidants, which neutralize superoxide. Oxygen can reduce and prevent oxidative damage to cells

　　"The body is in this state of balance, but with age, this balance is broken," said Giociayan, led by Professor Douglas Shields at the University of Colorado, whose Boulder branch is studying the physiology of aging. It is studying across the place. Gioscia-Ryan added: "This produces more active oxidants, which exceed their antioxidant defense capabilities." Cells in the elderly experience this phenomenon, called superoxide or other active oxidants, or oxidative stress. Excited. Mitochondria are one of the main sources of superoxide in senescent cells. These increased superoxides are not only related to NO, not only the endothelial layer reacts, but also can attack the mitochondria themselves. Damaged mitochondria gradually lose their function, produce more active oxidants, and mitochondria enter a bad cycle.

　　The focus of previous research is that long-term supplementation of antioxidants can improve blood vessel function-restore the balance of superoxide levels in patients with cardiovascular diseases. However, most studies show that this strategy is not very effective.

　　Research In this new research, mitochondria are a specific target antioxidant. Biochemists support MitoQ by adding molecules to Q10 (Translator's Note: Nivea's Advertising Coenzyme 10). This extra molecule can concentrate ubiquinone in the mitochondria

　　"The question is why you can't eat so much vitamin C." They believe that when taken orally, antioxidants such as vitamin C cannot enter the place where the reactive oxidation system is generated, and MitoQ can basically be traced back to the mitochondria. The results indicate that specific mitochondrial targeting strategies may be an effective way to effectively improve the function of aging arteries. By increasing the NO content in the arteries of aging mice, it reduces oxidative stress and improves mitochondria.