动物实验,糖尿病 z-bo 2020-09-01 414

　　Mouse diabetes induced by mouse diet is equivalent to human type 2 diabetes. A new study found that a single injection of FGF1 protein was enough to restore the blood glucose levels of mice to the normal range, and this effect of FGF1 lasted for more than 2 days. The discovery was completed by Salk scientists and has been published to the journal Nature. The new research results may lead to a new generation of safer and more effective anti-diabetic drugs.

　　The research team also found that continuous protein FGF1 treatment can not only control blood sugar, but also reverse insulin insensitivity, which is the fundamental physiological cause of diabetes. Similarly, the irritating newly discovered therapeutic protein FGF1 does not cause the common side effects of current antidiabetic drugs.

　　The purpose of diabetes drugs currently on the market is to increase insulin levels, reverse insulin resistance and lower blood sugar levels. However, drugs such as Vietta (which increase the body's insulin production) can lower blood sugar levels and cause life-threatening hypoglycemia and other side effects.

　　In 2012, Evans and his colleagues discovered that the long-ignored growth factor FGF1 has hidden functions. It can help the body respond to insulin. Mice lacking the growth factor FGF1 develop diabetes when they eat a high-fat diet. This finding indicates that FGF1 plays an important role in regulating blood glucose levels. Evans' team injected a single dose of FGF1 into diabetic obese mice to evaluate the potential effect of FGF1 protein on metabolism. The researchers were surprised to find that after a single dose of FGF1, the blood glucose levels of all diabetic mice dropped rapidly to normal levels. Many previous studies believe that injection of FGF1 will not affect healthy mice, but injection of FGF1 in diabetic mice can significantly improve glucose levels. Researchers have found that FGF1 treatment has many advantages compared with the diabetes drug pioglitazone (Actos). Pioglitazone has side effects and may cause weight gain and heart and liver problems. Importantly, high doses of FGF1 will not cause these side effects or dangerously lower blood glucose levels. On the contrary, FGF1 injection can restore insulin and its natural ability to regulate blood sugar, keep blood sugar in a safe range, and effectively reverse the main symptoms of diabetes. I can do it. It is not known that FGF1 can cause hypoglycemia or other common side effects. It is believed that this is because FGF1 is rapidly metabolized in the body and targets specific cell types. Currently, the mechanism by which FGF1 regulates blood sugar and insulin resistance is not fully understood. The signaling pathways and receptors that interact with FGF1 are the first problem researchers have to solve. In addition, we are planning to conduct human testing of FGF1, which involves fine-tuning the protein to make it a therapeutic drug.