动物实验,环磷酰胺 z-bo 2020-09-02 401

　　Objective: To explore whether pine pollen has a synergistic effect on cyclophosphamide chemotherapy.

　　Method: Using ascites S180 mice as the experimental system, testing tumor suppression, hematology and liver function indicators to evaluate the synergistic and inhibitory effects of pine pollen on cyclophosphamide chemotherapy. In a mouse model of immunodeficiency, an experimental system evaluates the immunomodulatory effects of pine pollen by detecting the phagocytosis of giant cells, the level of hemolysin, and the indicators of thymus and spleen.

　　Results: The combination of pine pollen (150, 300, 600 mg/kg) and cyclophosphamide can significantly increase the tumor inhibition rate, significantly reduce the loss of white blood cells and liver damage caused by cyclophosphamide. Yes, it can enhance the immunity of mice system. The phagocytic function of nuclear phagocytes, hemolysin levels and immune organ index.

　　Conclusion: Pine pollen can significantly improve the efficacy of cyclophosphamide chemotherapy and reduce toxicity by regulating immunity.