动物实验,高脂肪 z-bo 2020-09-02 422

　　The aroma of food is an important factor in inducing appetite. The study found that, according to foreign media reports, mice that temporarily lose their sense of smell while ingesting the same food are much lighter than control mice with normal sense of smell. This research was conducted at the University of California, Berkeley under the leadership of Professor Andrew Dilling and Professor Celine Riera. This involves the use of gene therapy to destroy olfactory neurons in the nose of adult mice, which causes the mice to lose their sense of smell for about 3 weeks. During this period, they and the control group both received a high-fat diet. Both groups ate the same amount of food, but the mice that temporarily lost their sense of smell only gained 10% of their body weight, while the mice in the normal control group gained about 100% of their normal body weight.

　　Next, the researchers turned the weight-gaining mice into "temporary smelling" mice. They found that even a high-fat diet can restore normal weight. At the same time, the researchers genetically engineered the mice to give them the characteristics of "super odor" and found that their weight was heavier than the control mice.

　　Scientists try to clearly understand what is happening, but they believe that fasting animals (including humans) are more sensitive to smell. Dilling said: "The sensory system plays a role in metabolism." "Weight gain reflects not only the calories burned, but also the way these calories are perceived. If we can verify this in the human body, it will not actually interfere with odors. It’s great to make drugs that can interfere with "circuits."

　　Unfortunately, when the smell of the mouse disappears, the level of norepinephrine rises significantly. This is a stress hormone related to the sympathetic nervous system. In humans, a constant rise can cause a heart attack. Nonetheless, researchers found it to be particularly valuable for obese people, for example, when the treatment lasts only about six months.