动物实验,钙螯合胶原多肽 z-bo 2020-09-02 373

　　Objective: To compare the effects of calcium chelated collagen peptides (CPCC) on the improvement of bone quality by estrogen, and to lay the foundation for the development of safe osteoporosis prevention and treatment drugs.

　　Methods: Two ovaries of rats were removed, ovariectomized group (OVX), sham operation group (sham), 17β-estradiol (OVX + E2) injection group and CPCC gavage group (OVX + CPCC), 9 groups . One week later, compare the bone and blood biochemical indicators of each group.

　　Result: The femoral bone density of the OVX group was significantly lower than that of the sham operation group (P0.05). However, in terms of weight gain inhibition, the weight of the E2 group was significantly lower than that of the sham operation group at the 8th and 9th weeks (P\u003c0.01). In terms of preventing the loss of bone minerals and organic matter, the Mg and Ca content of the E2 group was significantly lower than that of CPCC. The copper level of the high-dose group was similar to that of the sham operation group, but the CPCC (medium and low dose) was significantly higher than the sham operation group. The levels of Mn, Zn and hydroxyproline in the E2 group were significantly lower than those in the sham operation group, but CPCC could be maintained in the sham operation group. There was no significant difference between E2 group and OVX group in inhibiting the increase of blood BGP and StrACP levels, while CPCC group was significantly lower than OVX group. There was no significant difference between E2 group and OVX group in inhibiting the decrease of blood calcium concentration, but CPCC group was significantly higher than OVX group.

　　Conclusion: Calcium-chelated collagen peptide is more effective than estrogen in improving bone quality in ovariectomized rats.