动物实验,PCOS易感基因,宫蜕膜化 z-bo 2020-09-04 402

　　Objective: To study the expression and regulation of PCOS susceptibility gene Hmga2 in endometrial acceptance and decidualization.

　　Method: Use qPCR and Westernblot technology to explain the role of Hmga2 in endometrial receptivity through early pregnancy, delayed implantation and activation, artificial decidua, ovarian steroid therapy and other experiments.

　　Result: As the expression of pregnancy gradually increased, the expression of Hmga2 at the implantation point was significantly higher than that at the non-implantation point. The expression of embryo activation group was significantly higher than delayed implantation, artificially induced decidualization and non-decidualization. The expression of Hmga2 increases significantly, and the expression of Hmga2 is positively correlated with estrogen and progesterone, and is regulated by estrogen and progesterone in the body.

　　Conclusion: Hmga2 expression is closely related to the embryo implantation process of early pregnancy in mice, participates in the process of endometrial shedding, and is affected by activated blastocysts and steroid hormones.