动物实验,PM2.5 z-bo 2020-09-04 395

　　Objective: To investigate the effects of PM2.5 on the physiological functions of rat uterine tissues and related biochemical stress effects.

　　Method: 30 SD female rats were randomly divided into 3 different PM2.5 exposure groups (saline control group, 1.5 mg/kg PM2.5 low-dose group, 37.5 mg/kg PM2.5 high-dose group). They were divided into 10 days after exposure to PM2.5, and the female mice were sacrificed. The pathological changes of the uterine tissue were observed by HE staining, and the contents of SOD, GSH, MDA and LDH in the uterine tissue were detected.

　　Results: Compared with the control group, female mice exposed to PM2.5 had abnormal uterine structure, thinned endometrium epithelial cells, placed disorderly, and reduced intrinsic mesenchymal cells and blood vessels. Oxidative stress index test results showed that the high-dose group The contents of MDA and LDH were (6.53±1.24) nmol/mgprot and (265.62±24.65) U/gprot, respectively, which were significantly higher than those of the control group (P. The SOD and GSH contents of the low-dose group were significantly lower than those of the control group (P\ u003c0.05).

　　Conclusion: PM2.5 can destroy the uterine morphology of rats and induce uterine-related oxidative stress.