动物实验,肺动脉高压 z-bo 2020-09-04 446

　　Objective: To explore the relationship between changes in pulmonary artery pressure and changes in right ventricular function.

　　Methods: MCT-induced 4 pulmonary arterial hypertension (PAH) model groups (12 in each group), using right heart catheter to measure pulmonary artery pressure for 1, 2, 3, 4 weeks, MRI right heart function dynamics pulmonary artery detection and observation of pressure and MRI Changes in parameters. Compare the differences in related parameters between the control group and the PAH model group. Using SPSS17.0 statistical software, Pearson correlation analysis was used to evaluate the correlation between right ventricular ejection fraction, right ventricular end diastolic volume, right ventricular end systolic volume and mean pulmonary artery pressure. In order to compare between groups, we used a completely random t test, P\u003c0.05, which means that the difference is significant.

　　Results: The average pulmonary arterial pressure (rRVEF = -, respectively) of 48 model rats was good 1 to 4 weeks after right adrenaline injection, and the right ventricular ejection fraction, right ventricular end-diastolic and end-systolic volumes were well correlated. 0.823, rRVEDV = 0.732, rRVESV = 0.803). Two weeks before monosinapine injection, the mean pulmonary artery pressure, right ventricular ejection fraction, right ventricular end-diastolic and end-systolic volume of monosinapine were not significantly different from those of the control group (P\→0.05). After 3-4 weeks, the above parameters were significantly different from the control group (P\u003c0.05).

　　Conclusion: With the increase of pulmonary artery pressure in rats, the right ventricular ejection fraction gradually decreases, and the right ventricular end-diastolic and end-systolic volumes gradually increase. In order to monitor the rat model of chronic pulmonary hypertension, MRI can accurately and quickly measure the changes of various parameters. Parameters such as right ventricular end-diastolic and end-systolic volumes and ejection fraction are sensitive parameters that promote pulmonary hypertension.