动物实验,高脂血症心肌缺血 z-bo 2020-09-05 439

　　Objective: To observe the effect of Centella asiatica extract (TAE) on oxidative damage in mice with hyperlipidemia myocardial ischemia, and to preliminarily explore the protective effect of TAE on cardiovascular.

　　Method: Male KM mice were selected and randomly divided into control group, model group, simvastatin group, TAE high-dose group and low-dose group. Except for the control group, all other groups can drink milk freely instead of water to cause hyperlipidemia. disease. At the same time, the corresponding drugs were taken orally once a day for 28 days. 72 hours before the end of the test, three subcutaneous injections of isoprenaline hydrochloride (Iso) were used to establish a myocardial ischemia model. Mouse body weight, ECG, heart and liver indicators, myocardial water content, serum total cholesterol (total cholesterol, TC), triglycerides (TG), high density lipoprotein (HDL), low density lipoprotein (low density lipoprotein) ) Detection (LDL), superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GPx) activity.

　　Result: TAE improved the changes of myocardial ischemic ECG in model mice, reduced body weight, inhibited heart and liver indicators, decreased myocardial water, decreased serum TC, TG, LDL-C, and increased serum HDL-C. Serum MDA content will increase serum SOD and GPx activities.

　　Conclusion: TAE may regulate the metabolism of oxygen free radicals, improve oxidative damage, and play a role in cardiovascular protection.