动物实验,肾上腺髓质素 z-bo 2020-09-05 412

　　Objective: To investigate the effects of interstitial hormone (IMD) and adrenomedullin (ADM) on cerebral microcirculation in rats with focal cerebral ischemia.

　　Methods: The middle cerebral artery occlusion method was used to establish a cerebral ischemia (CI) rat model, and 40 SPF male SD rats were randomly divided into 3 groups: cerebral ischemia model + normal saline [CI] + S (normal saline, NS) ) Group, CI model + ADM treatment (CI + ADM) group and CI model + IMD treatment (CI + IMD) group, the changes in brain surface microcirculation perfusion were monitored by laser Doppler.

　　Results: Comparison of brain surface microcirculation perfusion in the CI + S group, CI + ADM group, and CI + IMD group was significant (P\u003c0.05). Later, rats in the CI + IMD group compared the brain several times The perfusion of surface microcirculation was higher than that of CI+S and CI+ADM groups.

　　Conclusion: IMD can improve cerebral microcirculation in rats with focal cerebral ischemia, and its effect is better than that of ADM.