动物实验,白藜芦醇,血液高凝态 z-bo 2020-09-05 384

　　Objective: To study the relationship between the effect of resveratrol on the formation of hypercoagulability in rats and the expression of NF-κB.

　　Methods: The SD rats were divided into blank group, model group, high-dose resveratrol group (60mg/kg), low-dose resveratrol group (30mg/kg), aspirin group (10mg/kg) and continuous infusion Note. It can be divided. Stomach was administered for 7 days, and adrenaline combined with ice bath method and thrombin method were used to establish a coagulation rat model, blood samples were collected, and prothrombin time (PT) and activated partial thromboplastin time (APTT) were measured. ) And whole blood viscosity; vascular endothelial cells were collected and the expression of NF-κB was determined by Western blotting.

　　Results: Compared with the model group, in the blank group, high-dose resveratrol group, aspirin group, PT and APTT were significantly prolonged (P≥0.05), and blood viscosity was significantly reduced (P≥0.05). u003c0.05). The expression of NF-κB in the high-dose resveratrol group was significantly lower than that in the model group (P\u003c0.05).

　　Conclusion: High-dose resveratrol (60 mg/kg) may inhibit the formation of hypercoagulability in rats, and this effect may be related to the decrease of NF-κB expression.