动物造模 z-bo 2020-09-05 394

　　In a mouse study published by American scientists in "Natural Neuroscience", a "dense" diet has become a daily choice for most people, but a high-salt diet can affect brain health. Found that it affects intestinal health. Changes in the immune system can lead to cognitive impairment, and changes in lifestyle can reverse this result. It is well known that a high-salt diet will increase human blood pressure and may increase the risk of cardiovascular disease. At the cellular level, excessive salt intake can cause endothelial cell dysfunction, which can affect the vascular tension on the inner surface of blood vessels, but the long-term effects of this dysfunction on various organs are unclear.

　　A research team at Weill Cornell College of Medicine now allows mice to eat a high-salt diet. This is the percentage of high salt content in some people's diet. A few weeks later, the mice developed abnormal endothelial cell function, reduced blood flow to the brain, and showed cognitive impairment in multiple behavioral tests, but there was no change in blood pressure. A high-salt diet also increased the number of TH17 white blood cells in the intestines of mice and increased the levels of pro-inflammatory molecules (IL-17) released from these cells. Researchers have found that a high-salt diet has a negative impact on cerebrovascular function, and the behavior is an increase in IL-17 in the blood. These are based on mouse experiments, but also show that IL-17 can similarly affect human brain vascular endothelial cells.

　　In other words, a high-salt diet will adversely affect human brain health. When mice return to a normal diet or undergo drug intervention, they can reverse the consequences of a high-salt diet, lifestyle changes or the development of new prescription drugs, thereby preventing or reversing the related consequences. It is worth mentioning what you can expect.