动物实验 z-bo 2020-09-05 490

　　According to foreign media reports, everyone wants to live long, but if you live long because of illness, do you think it makes sense even after 100 years? Therefore, instead of focusing on how to live longer, it is better to focus on how to improve the time we enjoy health, the "health span".

　　A recent study from Brown University found that the protein Sirt4 can extend the healthy lifespan of fruit flies. This finding may also apply to humans. Certuin is involved in metabolic processes and is associated with aging and age-related diseases. Researchers at Brown University first conducted experiments with fruit flies to study their effects and how to control them to extend healthy life. Of the seven sirtuins in human cells, three are found in the energy-producing mitochondria of the cell. Since Drosophila has only one mitochondrial sirtuin, Sirt4 is a very suitable experimental object. in

　　In the experiment, scientists divided fruit flies into two groups. One group had excess Sirt4 and the other group could not produce any protein. The results showed that the healthy life span of fruit flies added with Sirt4 was 20% longer than other groups. The researchers also found that in the absence of food, fruit flies that do not contain Sirt4 are more likely to starve to death than fruit flies that contain a lot of Sirt4. The former group of fruit flies also had nutrients and fat in their bodies, and could not obtain these reserves. This suggests that Sirt4 may act as a "fuel switch" during fasting, turning burned carbohydrates into burned fat.

　　The lead author of this study, Stephen Hellfund (Stephen Hellfund) pointed out that Sirt4 is a very attractive object that can help improve metabolic disorders and extend healthy life.

　　Next, Brown University scientists continue to study Sirt4, including elucidating how Sirt4 is activated and its function in mammals, especially humans.