【Animal Modeling】-The mechanism of urbanization to extend the duration of animal-borne infectious diseases

  Tian Huaiyu, a teacher at Beijing Normal University, Hunan University, Hunan Center for Disease Control and Prevention, and the Institute of Global Warming and Earth Sciences at the University of Oslo, Norway, published an article on PNAS showing that China suffers from rapid urbanization with renal syndrome (HFRS prolongs bleeding) The heat and the duration of the epidemic point to two opposite impact mechanisms, that is, the rapid urbanization process brought about by the rapid development of the Chinese economy will drive the epidemic of animal infectious diseases.

  With the rapid development of China's economy in the past half century, the process of urbanization has accelerated. At the same time, the epidemic of infectious diseases caused by urbanization and the potential impact of corresponding disease control strategies on disease incidence have also received widespread attention. On the one hand, the process of urbanization may have affected the development of infectious diseases. For example, in Europe in the 19th century, many cities suffered "urban fines" due to infectious diseases, resulting in more deaths than births, and urban development complemented the immigrant population.

  On the other hand, urbanization tends to improve infrastructure and health conditions, as well as health care services. It is generally believed that urbanization can help improve health conditions in all aspects. Therefore, the relationship between urbanization and public health is very complicated. At present, the systematic understanding of the relationship between urbanization and infectious diseases is still insufficient. Hemorrhagic fever with renal syndrome is an infectious disease caused by Hantavirus infection. It is characterized by rapid spread, severe disease, and high mortality. It is a legally reported infection in China. Is classified as a disease. Hantavirus mainly carries rodents and spreads in the air together with the excrement, saliva and urine of infected animals, while humans mainly inhale polluted air and become infected by the disease. Because of the different subtypes of the infected virus, the clinical manifestations vary greatly, with mortality ranging from 0.5% to 40%. The number of reported cases of the disease in China exceeds 1.4 million, accounting for 90% of the total number of cases in the world. Epidemiological evidence shows that in areas with high migration rates, high density and poor living conditions, humans are more likely to come into contact with rodents carrying the virus, and the risk of infection is higher. However, Tian Huaiyu and colleagues found that the prevalence of hemorrhagic fever with renal syndrome is consistent with urban expansion and migration. At the same time, there is a two-level inverted U-shaped relationship between the incidence of HFRS and the level of urbanization. The turning point of this fashion has to do with the economy of the city. The growth rate is related. Research reveals the interrelationship between urbanization, immigration, and the Hantavirus epidemic, which provides a possible explanation for the long-term epidemic in fast-growing cities.