动物造模,肠道微生物 z-bo 2022-02-04 417

　　Changes in the intestinal flora have changed the activity of immune cells in the brains of experimental multiple sclerosis (MS) mice. This research may help us understand the interaction between the intestine and the brain, or help develop new therapies for multiple sclerosis and other neurological diseases. Multiple sclerosis arouses the normal brain immune system and activates non-neuronal cells (microglia and astrocytes).

　　Francisco Quintana of Harvard Medical School in the United States and his colleagues asked how the metabolite of dietary tryptophan produced by intestinal bacteria can block the pro-inflammatory of these two cells in a mouse model of multiple sclerosis active. I showed you that further research on multiple sclerosis brain tissue shows that a similar mechanism exists in the human brain. Aromatic hydrocarbon receptors limit the inflammatory transcriptional response of microglia during encephalomyelitis.

　　"The binding of dietary tryptophan metabolites to specific cell surface receptors changes the activity of these immune cells. The same receptor also binds to other natural compounds, including plant-derived derivatives such as broccoli. Perhaps one day, therapies targeting components of related molecular pathways will prove useful in the treatment of multiple sclerosis, but this study also found that inflammatory encephalopathy is caused indirectly through the intestine, which also indicates that it may be suppressed.