动物造模,细胞自噬 z-bo 2022-02-05 357

　　Autophagy is an evolutionarily conserved proteolytic pathway, which eliminates and recovers abnormal cellular components. Although it helps extend the lifespan of model organisms, it does play a role in mammalian life.

　　is little known. Beth Levine and colleagues at the University of Texas Southwestern Medical Center have previously shown that certain mutations in the protein beclin1 increase brain and muscle autophagy in mice and also improve mouse models of Alzheimer's disease. Cognitive function. We now report that these mice not only live longer, but also have a healthy lifespan due to reduced aging-related phenotypes (such as heart and kidney disease and tumors).

　　The same beclin1 mutation can also solve the problem of premature death and infertility in mice caused by insufficient anti-aging protein klotho. The authors pointed out that this mutation works by releasing beclin1 from a negative regulator, which is an effective mechanism for mammals to increase autophagy, prevent premature aging and prolong health and longevity. I came to a conclusion.