动物实验,基因编辑 z-bo 2020-09-08 367

　　Can cancer cells be modified to kill them? With the help of gene editing technology, American researchers are conducting experiments in this field and have achieved "promising" experimental results in animal models of various cancer cell types.

　　Brigham and Women’s Hospital and other institutions said in the new issue of the American Journal of Translational Medicine that cancer cells can track the same types of cancer cells in the same organ or spread to other parts of the body. I am reporting. "Anti-cancer-related cancer" research has promoted the use of this "auto-induction" ability of cancer cells to overcome the difficulty of delivering therapeutic agents to tumor sites.

　　Researchers tested improved cancer cells obtained in two different ways. One is to pre-engineer cancer cells to match the phenotype of the patient's human leukocyte antigen system. This is basically equivalent to the phenotype of the human leukocyte antigen system. The human immune system is the "fingerprint". Another option is to use CRISPR gene editing technology to edit patients' cancer cells and insert therapeutic molecules. These modified cancer cells are eventually returned to the patient. Experimental results on primary, recurrent, and metastatic brain and breast cancer mice showed that the modified cancer cells directly enter the tumor site and specifically attack recurrent and metastatic mice.

　　It has been shown that tumors that can kill mice can prolong the survival time of mice. The researchers pointed out that the modified cancer cells are equipped with a "self-destruct switch" that can activate it after treatment is over. Related image results show that the modified cancer cells died after activating the "self-destruct switch".