动物造模,高脂血症 z-bo 2020-09-08 416

　　Objective: To study the regulating effect of reed root polysaccharide on hyperlipidemia rats.

　　Methods: Thirty-two SD rats were randomly divided into 4 groups: the control group, the model group, the reed root polysaccharide group and the Lipitor group (8 in each group). The control group was given ordinary diet, and the other three groups were given high-fat diet. After 8 weeks of feeding, rats in the reed root polysaccharide group [200 mg/(kg·d)] and Lipitor group [2 mg/(kg·d)] rats were given the corresponding drugs respectively, the control group and the model group rats Gavage with normal saline for 6 weeks and then collect blood, separate the serum to detect the four levels of lipids, and take the liver and aorta for histopathological examination.

　　Results: Compared with the control group, the serum triglyceride (TG) level of the model group was significantly reduced (P<0.01), total cholesterol (total cholesterol, TC), high-density lipoprotein cholesterol (high-density lipoprotein cholesterol) and high-density lipoprotein cholesterol (TG) levels were significantly reduced (P <0.01). -Cholesterol, HDL-C) and low-density lipoprotein cholesterol (low-density lipoprotein-cholesterol, LDL-C) levels increased significantly (P <0.01); the serum levels of the polysaccharides group and Lipitor group D of CH Both -C and LDL-C are significantly lower than the model group (P <0.01). Rats in the model group showed extensive hepatocyte steatosis and inflammatory cells. Rats in the reed root polysaccharide group and Lipitor group showed limited hepatocyte steatosis and the degree of disease was reduced.

　　Conclusion: Reed root polysaccharide can reduce the levels of TC and LDL-C in hyperlipidemia rats, reduce hepatocyte steatosis, and have a better regulatory effect on hyperlipidemia rats.