动物实验 z-bo 2020-09-08 421

　　The latest research shows that the high-fat diet of female mice can affect obesity, insulin resistance and dependent behavior of the offspring of three generations. Researchers at the Swiss Federal Institute of Technology Zurich found that the second-generation offspring (ie offspring) of mice that ate a high-fat diet before, during, and after pregnancy were susceptible to drug infection. Discovery is increasing. Drugs have addictive behaviors, such as taste, and obesity-related characteristics, such as metabolic changes. In the third generation of offspring (i.e., great-grandchildren), the researchers observed some gender differences, with only women showing habitual behavior and only men obese. The first female mice were not obese by themselves, and later mice lacked a high-fat diet, but the above situation still occurs.

　　Corresponding author Daria Peleg-Raibstein said: "So far, most studies have only observed the second generation of offspring, or only observed the long-term effects of obesity and diabetes on the first generation of offspring. Researchers and researchers recently published in " These effects were found in a report in the journal Translational Psychiatry, especially in male offspring. These findings are the effects of maternal overeating on drunkenness and obesity. We have analyzed the effects of third generation offspring transmission. Theirs The method is to give female mice a high-fat or normal diet before mating, during pregnancy and 9 weeks of lactation. Then the male offspring of these mice and female mice are raised on a standard diet to produce the second generation of offspring. Under a standard diet, the male offspring of the second generation offspring were crossed with female mice to produce the third generation offspring. The researchers measured the weight, insulin sensitivity, metabolic rate and related blood of the second and third generation offspring. Indicators (such as insulin and cholesterol levels). Behavioral studies investigated whether mice prefer a high-fat diet over a standard experimental diet, or an alcohol solution over water, and their activity level after using amphetamine (amphetamine). This is to better understand whether the mother’s ancestors’ high-fat diet will affect the offspring’s obesity, overeating and drug sensitivity.

　　Peleg-Raibstein said: "In order to combat the current obesity epidemic, it is important to understand the mechanisms behind it and find ways to prevent obesity early. The latest research shows that health counseling and education are provided for pregnant and lactating couples. Helping to improve children, grandchildren and great-grandchildren are more likely to lead a healthy life. This provides potentially useful ways to discover high-risk factors for obesity and addiction and provides suggestions for early intervention for high-risk groups."

　　"The conclusions drawn from Soso General Mouse still apply to humans, and there is still a long way to go," Peleg-Raibstein said. I will add it. "However, because there are too many interfering factors, it is almost impossible to study the effects of binge eating on human mothers. There are many things, such as socioeconomic background, parental dietary preferences or current health conditions. By using mouse models, we The impact of a high-fat diet on offspring can be studied without disturbing these factors."

　　Researchers have also determined the molecular mechanism of the effect of high-fat diet on women. This requires further research.