动物造模,放射性心脏损 z-bo 2023-01-14 624

　　During radiotherapy of chest and abdomen tumors, the heart located in the mediastinum is inevitably exposed to heart damage caused by radiation, collectively referred to as radiation-induced heart damage (RIHD).This disease has been considered as important as traditional radiation-induced pulmonary fibrosis. Severe radiotherapy side effects. In recent years, scholars have gradually heated up research on RIHD. At present, there are many clinical observations in this field, basic research is insufficient, and the etiological mechanism is still unclear. It is still in the stage of "cognition". Effective intervention measures. Therefore, the use of animal experiments for basic research on RIHD, in-depth exploration of the pathological molecular mechanism of heart damage caused by radiation, and active attempts of possible intervention methods are of urgent practical significance. This article focuses on animal modeling, index detection, and pathological mechanisms in experimental research. ､Summarize the basic research results of RIHD on drug intervention and its pharmacological effects, hoping to provide a certain reference for future RIHD research.