动物实验 z-bo 2020-09-09 385

　　Objective: How to study the effects of AIDS acute inflammation factors, lipid metabolism and glucose metabolism on body weight?

　　Methods: Using acute-phase inflammatory factors (TNF-α? IL-6) and lipid metabolism (cholesterol? Pearson correlation analysis) to find the difference between weight gain and weight loss groups in Biping-top monkeys with SIV infection The relationship with plasma viral load to compare triacylglycerols, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and glucose metabolism parameters (insulin-insulin resistance index)?

　　Results: In the acute phase of SIVmac239 infection in Beiping-top monkeys, there was no significant difference between the four inflammatory factors and blood lipids in the weight gain and weight loss groups. The insulin level in the weight loss group was significantly reduced, significantly increased, and showed insulin resistance; Pearson analysis showed that the change of insulin resistance index at 5 and 11 weeks after infection was positively correlated with plasma viral load.

　　Conclusion: During the acute SIVmac239 infection, will abnormal glucose metabolism be the main cause of weight changes in Beiping monkeys?