动物造模,椎间盘脱出 z-bo 2020-09-09 390

　　Objective: To observe the effects of electroacupuncture combined with methylprednisolone and electroacupuncture alone or methylprednisolone alone on the motor function of the limbs and nerve cells in rats with intervertebral disc herniation after 24 hours to provide a basis for clinical application?

　　Method: Did you randomly divide 112 SD rats into sham operation group (sham operation)? Model (model)? Acupuncture combined with methylprednisolone group (EA + MP)? Electroacupuncture group (EA) and methylprednisolone group (MP), using self-made silicone gasket compression method to prepare intervertebral disc herniation models, treat each group separately, at different time points BBB limb motor function scores Are you stained by Nissl Perform or collect spinal cord tissue and observe the changes and side effects and side effects of Nisle bodies in neurons?

　　Results: 1) BBB score, each group tends to increase after treatment, the EA + MP group is significantly higher than the EA group and MP group when the hind limbs are compressed for 3-7 days (P0.05). (2) Compared with the model group, the Nissl staining of each treatment group showed less neuronal damage and more Nissl bodies. Among them, is the EA + MP group better than the other two groups? (3) The incidence of side effects, 30% in MP group, 4.16% in EA + MP group, 0 in EA group; mortality, 20% in MP group, 0% in EA + MP group and EA group?

　　Conclusion: 24 kinds of intervertebral disc degeneration rats can increase the number of small bodies through three treatment methods, maintaining neuronal morphology and improving limb motor function (the time frame of methylprednisolone action) exceeds). Among them, EA + MP is the most effective, which can significantly reduce the side effects and mortality of MP treatment. Is the emergence of EA better than the efficacy of EA alone?