[Animal modeling]-Myocardial contrast echocardiography visually assesses the microcirculation in rabbits after acute myocardial infarction

  Purpose: Apply the visual assessment method of myocardial contrast echocardiography to the rabbit acute myocardial infarction model to evaluate the blood perfusion of the infarcted area after acute myocardial infarction?

  Method: The 20th group of clean Japanese big-eared rabbit model group (group A) and sham operation control group (group S) will randomly establish acute myocardial infarction in about 20-45 minutes of ECG examination. , Collected before surgery and within 20 minutes to 2 hours to 6 hours. Comparison of conventional ultrasound and ultrasound, comprehensive evaluation and analysis of rabbits What is the segmental blood perfusion model after acute myocardial infarction? After the experiment, will the modeled myocardial tissue be partially excised for pathological examination?

  Results: Routine echocardiography showed a series of segmental motions at different time points after ischemia, significant changes, significant changes in myocardial histology, Japanese also showed that the acute myocardial infarction model of the big-ear rabbit was successfully established, myocardial contrast echocardiography The visual evaluation of the figure shows that the myocardial blood volume and perfusion rate of the model part of the A group are significantly lower than the corresponding segments of the non-infarct segment of the S group. Is it consistent with the results of conventional echocardiography and histopathology?

  Conclusion: The visual assessment of myocardial contrast echocardiography can accurately determine the blood perfusion status of the infarcted myocardial segment after acute myocardial infarction. What is an effective diagnostic method?