动物造模,糖尿病,黄连多糖 z-bo 2020-09-10 403

　　Objective: To study the protective effect of Rhizoma Coptidis polysaccharide on nephropathy in diabetic rats and its underlying mechanism

　　Method: Intraperitoneal injection of STZ (60 mg/kg) to establish a diabetic rat model? Coptis high-dose (300 mg/kg/d), low-dose (100 mg/kg/d) and rosartan potassium group (30 mg/kg/d) 10 rats and 10 SD rats were selected as normal group. After intragastric administration for 1 week/d8 weeks, the weight of diabetic rats, kidney weight to body weight ratio, BUN, Scr, 24-hour urine protein, kidney histopathology, SOD, CAT, GSH-Px, MDA, IL we tested The role of Coptis polysaccharides. -6? The influence of hs-CRP and TNF-α expression

　　Result: Compared with the model group, the weight of rats in the Coptis polysaccharide group increased significantly, but the ratio of kidney weight to body weight decreased significantly. Meanwhile, BUN? The 24-hour urine protein was significantly reduced, and the pathological morphology of kidney tissue was significantly reduced. Is Rhizoma Coptidis SOD of kidney tissue? Cat? Increase GSH-Px activity and MDA content in kidney tissue and serum IL-6? You can also reduce the content of hs-CRP and TNF-α. Rhizoma Coptidis polysaccharide can reduce kidney damage in diabetic rats. This effect is related to oxidative stress and inflammation suppression