[Animal Modeling]-Three kinds of stem cells needed to transform experimental mouse skin cells into embryos

  In the "Cell-Stem Cell" released in the United States, Israeli researchers transformed skin cells into the three main stem cells required for early embryos in animal experiments, transformed into embryos, placenta, umbilical cord and other tissues. According to reports, stem cells can differentiate.

  This result is not only very important for studying embryo and fetal position defects, solving certain infertility, but also in the future, using human skin cells without sperm or eggs will be perfect. This also means that it is possible to grow. Human embryo.

  In early 2006, Japanese researchers could "reprogram" adult skin cells to restore them to a state similar to natural embryonic stem cells and re-differentiate into various organs and tissues. I found out. They are called "artificial pluripotent stem cells". In recent years, researchers have used artificial pluripotent stem cells to cultivate various cells, such as cardiomyocytes and liver cells, but they have not been able to use them to cultivate tissues, such as placenta. Researchers at the Hebrew University of Israel found that after a set of five genes were introduced into the skin cells of experimental mice, the skin cells were transformed into three types of stem cells at the same time, namely embryos, placenta, and umbilical cord. I found it can be further differentiated. According to reports, some researchers tried to reproduce experimental mouse embryos without sperm and eggs, but used these three kinds of stem cells isolated from the relevant tissues of living experimental mouse embryos. done. Reculture of experimental mouse embryos. According to this study, it is possible to use skin cells to culture experimental mouse embryos in vitro without "sacrificing" live embryos.