动物造模,肠道微生物群 z-bo 2020-09-11 439

　　In the past few years, scientists have discovered that the intestinal flora of humans and other animals plays a much more important role in maintaining health than previously thought. In addition to processed foods, the intestinal flora also plays an important role in the immunity and regulation of cholesterol and triglycerides. The imbalance of intestinal flora is related to Crohn's disease, irritable bowel syndrome and other inflammatory diseases. The researchers currently engaged in this new study have found new evidence that, at least in mice, the intestinal flora can also maintain the proper number and function of skeletal muscle.

　　Skeletal muscle is one of the three main muscle types, the other two are the heart type and the smooth type. Skeletal muscles sound like a series of muscles connected to bones. These bones are in motion, especially controlling the limbs. To better understand the impact of the microbiota on skeletal muscle quality, the researchers obtained several wild mice and compared them with sterile mice (mice without any microbiota). .. Compared with wild mice, sterile mice have skeletal muscle atrophy. Low expression of chemicals that support muscle growth. The researchers found that the levels of various amino acids in mice lacking the microbiome were higher than normal. This is a sign of liver problems. They also found low levels of acetylcholine precursors in mice. Acetylcholine is a neurotransmitter involved in signal transmission between skeletal muscles and nerves. The researchers also found that transplanting substances containing wild mouse gut microbes into the intestines of sterile mice increased muscle mass and function. They also found that feeding sterile mice with fatty acids normally produced by gut microbes can also partially restore muscle mass.