动物实验,卵巢功能 z-bo 2020-09-11 365

　　Objective: How to evaluate the effect of high-fat diet-induced obesity on the ovarian function of female rats and its mechanism?

　　Methods: 80 Wistar female rats were randomly separated from the high-fat diet (HFD) group (n = 40). Meals (control group) (n = 40)? After sixty days of feeding, the estrus cycle and cell number of each group of rats and the apoptosis of each stage of rat follicular development were evaluated, and the serum progesterone and estradiol levels of each group of rats were measured. Then, did you place the male and female rats in a 1:2 cage for 3 weeks?

　　Result: HDF induced obesity and hyperglycemia in rats, but did it affect the levels of serum triglycerides, cholesterol and C-reactive protein in rats? Obesity has also changed: ovarian function, the interval between estrus in HFD rats is prolonged, the serum estradiol level is reduced, and the number of sinus closures increases? In addition, do rats in the HFD group also develop follicular cysts? Moreover, did the rats in the HFD group become pregnant later than the control group?

　　Conclusion: Does obesity induce follicular cysts in rats, prevent ovulation and delay pregnancy?