动物实验 z-bo 2020-09-11 396

　　If you think it is safe to drink one or two glasses of alcohol on special occasions during pregnancy, please think again. A study in the Journal of Physiology showed that even a small amount of alcohol during pregnancy can cause insulin resistance in the offspring of male rats, thereby increasing the possibility of diabetes.

　　This study imitates "drinking on special occasions", such as family barbecues and birthday parties. In this case, it is recommended that pregnant mothers drink one or two alcoholic beverages. Male rats exposed to this low level of prenatal alcohol showed signs of diabetes approximately 6 months after birth. The researchers only fed the female mice for two days. The blood alcohol level in the mice only reached 0.05%, but their offspring were almost diabetic, and their insulin levels reached the level to maintain normal blood sugar levels. Another interesting finding is that insulin resistance is sex-specific and only occurs in male rats. There are two possible reasons for this situation. One is the different ability of the placenta to adapt to fetal stress during pregnancy. It will affect the growth and development of the fetus.

　　Another factor is hormonal changes in adult offspring. In this case, estrogen can resist insulin resistance, and because male estrogen levels are not high, the same protection cannot be obtained.

　　The lead author of the study commented on Lisa Akison, a researcher at the University of Queensland:

　　"A small amount of alcohol during pregnancy may be harmful, so I plan to get pregnant. If you do, don’t drink alcohol. Family partners and friends need to support women so that they can choose not to drink alcohol during pregnancy. Women who become pregnant are unintentionally pregnant. Drink alcohol unconsciously during the stage. If you drink it, once you know it, stop drinking and maintain good eating habits. This is important during pregnancy. Take care of yourself during the rest of the process.