动物实验,免疫治疗反应 z-bo 2020-09-11 364

　　Roberto Peley, MD, Professor of Oncology at Indiana University School of Medicine Roberto Wallace Miller Melvin, and Roberto Peley, a researcher at the Bren Simon Cancer Center, and colleagues said , Prostate cancer and breast cancer will slow the growth of tumors.

　　In a recent study, the research team reported that reducing protein intake from 20% to 10% can improve the response of mouse models to immunotherapy. Immunotherapy is a therapy that uses the immune system to fight cancer and other diseases.

　　"This is very important because today's immunotherapy and immune checkpoint inhibitors have become the standard for the treatment of many solid tumors. It can be applied to all types of cancer patients. The nationally recognized expert on prostate cancer, kidney cancer and bladder cancer, said Piri :"I believe. "The study was published online in Journal Clinical Canceresearch on September 6.

　　It is usually recommended to eat a high-protein diet because the weight will be lost during the treatment.

　　However, Piri’s early work supports the hypothesis that by changing the patient’s diet (for example, limiting the amount of protein in the diet), the patient may still benefit from immunotherapy.

　　Skinri said: "Our goal is to study how to change the diet of people who already have cancer and allow them to benefit from this dietary change."

　　Why do you limit protein? Pili pointed out that the diet is high in protein. Humans (animal fat, dairy products, lean meat) are more susceptible to cancer. At the same time, a diet rich in vegetables, beans and fish can reduce the incidence of cancer.

　　Pili compares a restrictive protein diet with brakes because it can help reduce the immunosuppressive effects of certain cancer patients. Immune suppression may be the reason why some patients do not respond to immunotherapy, because current drugs (such as immune checkpoint inhibitors) open up barriers to the immune system. If the brake is not completely released, the medicine will be ineffective. If we reduce the effects of braking through diet, we can actually suppress the immune suppression mechanism and better release the immune response. "Further research will be conducted so that we can learn more about dietary changes (especially protein restriction) and the role of immunotherapy in cancer patients. Our preliminary results indicate that changes in eating habits can lead to better immunotherapy. Response, and reduce invasive treatments in the future."

　　Piri is the lead researcher of the IU Simon Cancer Center for clinical trials of patients with prostate cancer immunotherapy. In this trial, patients were randomly selected and received the usual protein treatment or reduced protein diet.