动物实验,多氯联苯 z-bo 2020-09-11 440

　　Neuroscientists at Georgetown University Medical Center say that endless artificial toxic chemicals in the environment can damage the function of key auxiliary cells in the mouse brain and cause dysfunction after long-term exposure.

　　Their research is considered to be the first test of stellar polychlorinated biphenyls (PCBs), which can support neurons and are essential for the homeostasis of the entire central nervous system. Studies have shown that this persistent environmental toxic substance may be a factor in the development of astrocytes. Neurodegenerative diseases. They presented their findings at the annual meeting of the Society of Neuroscience in Chicago. This research conducted in a laboratory study of mouse brain cells shows how the once-widely used mixture of polychlorinated biphenyls can open the way for stellate cells to try to neutralize toxins. Montna McCann, the lead researcher and PhD candidate of the Georgetown Interdisciplinary Program in Neuroscience, said that many antioxidant genes known to be associated with human neurodegeneration have been found in mouse cells. He said it will be activated abnormally. Matane in

　　Research in Catherine Magwire’s laboratory shows: “So far, these toxins are closely related to the health of stellate cells and can maintain brain function. Dr. Zeiss, Director of the Department of Neuroscience, Georgetown University

　　These stellate cells maintain the blood-brain barrier, support neurons and regulate nerves. After injury and possible completion of many other supportive tasks, cell-to-cell communication and nerve tissue repair have been performed to maintain the homeostasis (physiological stability) of the entire brain. essential. "It is well known that PCBs can cause cancer, suppress the immune system, disrupt hormone signals and impair reproduction. Post-mortem studies have shown that the brains of Parkinson's disease patients are black. It is also related to the death of cells (cells that produce dopamine).

　　PCBs have chemical stability, heat resistance and electrical insulation, so PCBs are produced and widely used worldwide. For products that have become coolants, flame retardants, lubricants, paints, adhesives and many other industries, their use was banned in some countries in the 1970s and 1980s due to their toxicity. However, global production did not stop until 2001.

　　Wheat? Point out that the effects of these toxins will continue, and because of their useful stability, they can also be maintained in the environment. "

　　In addition to certain human diseases, PCBs have recently been associated with the decline in shark populations. McCann said that the combination of environmental stressors (such as PCBs and genetic susceptibility factors) is associated with neurodegeneration.

　　McCann said: "People in certain areas are exposed to low-dose PCBs and other similar compounds for a long time in their lives." "The results of our laboratory research show that this accumulation can cause oxidative stress in stellate cells. So that they cannot support the neurons they maintain."

　　It is impossible to remove accumulated PCBs from humans, but if human studies show that certain pathways in the brain are affected, then it can make up for the lack of functions of the stars. She said: "This is clinically possible. Compensation mechanisms can be used to buffer these toxic substances and improve the ability of cells to promote survival."