动物实验 z-bo 2020-09-11 426

　　Reducing food intake can help animals and humans improve the health of the elderly and extend their lives. But when do you need to change your eating habits to get this benefit in old age? Scientists from the Max Planck Institute for Aging Biology at the University of Cambridge and scientists from the outstanding aging research team at the University of Cologne UCL began to eat less and eat less before aging. This is the age. Scientists have concluded that in order to improve the health of older people and prolong their lives, healthy behaviors must be established early in their lives.

　　How can I stay healthy for as long as possible? Elderly researchers have a simple answer, which is to eat less and more to become healthy. But when does it need to be restored? Is it enough to complete this operation in a short time? To study this, in an animal experiment led by Linda Partridge of Linda Patrice, director of the Max Planck Institute for Aging Biology, researchers controlled The diet of adult mice and adult mice has achieved varying degrees of success. I put it in

　　Elderly people do not help reduce food intake

　　eat 40% less than the animals that adult mice can eat, which makes them live longer and healthier. Dieting mice should be fed foods rich in vitamins and minerals to prevent malnutrition. However, it has been found that when the rat is old, reducing the rat's food intake first reduces the amount of food eaten first, which has little effect on the life expectancy of the rat. On the other hand, after reducing food intake for a period of time, free feeding of mice does not provide long-term protection, so it is necessary to continue to reduce food intake to benefit the mice. Therefore, in order to have a positive impact on the health of the elderly, it is necessary to reduce food intake as soon as possible and maintain it to the end of life. Linda Partridge of the Max Planck Institute for Aging Biology explains: “People need to establish healthy behaviors early in life. Changing diets later in life may not be good for health. Benefits. The health of the elderly is lifelong. "UCL.

　　adipose tissue memory effect

　　But why do older mice stop responding to dietary changes? The lead author of the study and a PhD student Oliver Hahn at Partridge College studied gene activity in various organs. Scientists have observed that due to the restricted diet of mice, the genetic activity in the liver adapts quickly, which produces a "memory effect" on the fat tissue of the elderly animals. The mice lost weight, but the genetic activity of adipose tissue was similar to that of mice continuing to eat the required number. In addition, the fat composition of old mice is not as good as that of young mice. This memory effect mainly affects mitochondria, which play an important role in the aging process. Generally, reduced food intake leads to increased mitochondrial formation in adipose tissue. However, studies have shown that this is no longer the case when old mice switch to a low-calorie diet. The life span of these animals can be shortened because they cannot change at the genetic and metabolic levels.

　　Michael Wakelam, the corresponding author and director of the Babraham Institute, commented: “Compare the lipid metabolism and metabolic pathway data with a tissue-specific understanding of the gene expression of mice of different ages and diets. The combined experimental ability proves the importance of nutritional memory in promoting healthy aging."