动物实验,花生过敏 z-bo 2020-09-11 365

　　New research shows that the vaccine can successfully eliminate peanut allergy in mice.

　　According to the Mary Wieser Food Allergy Center of the University of Michigan, only one injection of the nasal vaccine every three months can protect mice from allergic reactions after exposure to peanuts.

　　This research was funded by Food Allergy Research and Education (FARE) and the Ministry of National Defense, and was published in the Journal of Allergy and Clinical Immunology. UM researchers have spent nearly 20 years developing vaccine formulations, but recently turned this research into a vaccine for the treatment of food allergies. In this new study, immunizing mice allergic to peanuts may change the way immune cells respond to peanut allergy. The new method activates another immune response that can prevent allergic symptoms.

　　First author Jessicao Coneck said: Researchers at the Food Allergy Center said: "We are changing the way immune cells respond to allergens." "The important thing is that you can do it after the allergy is established. Perform this operation. This opens up possibilities for the treatment of human allergies."

　　"By changing the immune response, the vaccine not only suppresses the response,

　　The mouse model studied by

　　also has peanut allergic reactions similar to those in infected humans, including itchy skin and difficulty breathing. Two weeks later, this study evaluated the protection against allergic reactions. Although research is ongoing to determine the duration of the protective effect, encouraging researchers to use this method is a long-term allergic reaction. Lead to inhibition.

　　This discovery is another step in potential clinical trials of testing methods in humans.

　　O'Konek said: “Currently, the only food allergy solution approved by the FDA is to avoid food or suppress an allergic reaction that has already started.”

　　The next step is to better understand the mechanisms that inhibit food allergy. Further mouse research aims to understand whether the protective effect of peanut allergy can be extended or even longer.

　　UMMaryH’s lead author James Baker, MD, said: “The prevalence and incidence of food allergies are rising sharply, but we don’t know much about it because there is not much research in this area.”